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1
The Tpr protein: linking structure and function in the nuclear interior?Tpr蛋白：连接细胞核内部的结构与功能？
Am J Hum Genet. 1998 Aug;63(2):305-10. doi: 10.1086/301989.
2
Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex.致癌基因激活基因Tpr的产物是一种核孔复合体的磷酸化蛋白。
J Cell Biochem. 1996 Apr;61(1):48-60. doi: 10.1002/(sici)1097-4644(19960401)61:1<48::aid-jcb7>3.0.co;2-2.
3
Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket.核孔蛋白作为核孔复合体核心结构的组成部分，而Tpr作为核篮的结构元件。
Mol Biol Cell. 2004 Sep;15(9):4261-77. doi: 10.1091/mbc.e04-03-0165. Epub 2004 Jun 30.
4
Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments.鉴定蛋白质p270/Tpr为核孔复合体附着的核内细丝的组成成分。
J Cell Biol. 1997 Feb 10;136(3):515-29. doi: 10.1083/jcb.136.3.515.
5
Amino acid substitutions of coiled-coil protein Tpr abrogate anchorage to the nuclear pore complex but not parallel, in-register homodimerization.卷曲螺旋蛋白Tpr的氨基酸替换消除了其与核孔复合体的锚定作用，但并未影响其平行、对齐的同二聚化。
Mol Biol Cell. 2001 Aug;12(8):2433-52. doi: 10.1091/mbc.12.8.2433.
6
Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export.转运蛋白受体（Tpr）定位于核孔复合体的核篮中，并在核蛋白输出中发挥作用。
J Cell Biol. 2002 Feb 18;156(4):617-30. doi: 10.1083/jcb.200106046. Epub 2002 Feb 11.
7
Molecular segments of protein Tpr that confer nuclear targeting and association with the nuclear pore complex.赋予核靶向作用并与核孔复合体结合的蛋白质Tpr的分子片段。
Exp Cell Res. 1998 Nov 25;245(1):43-56. doi: 10.1006/excr.1998.4246.
8
Structures and dynamics of Drosophila Tpr inconsistent with a static, filamentous structure.果蝇Tpr的结构与动力学与静态丝状结构不符。
Exp Cell Res. 2002 Jun 10;276(2):223-32. doi: 10.1006/excr.2002.5525.
9
Tpr regulates the total number of nuclear pore complexes per cell nucleus.Tpr 调节每个细胞核内核孔复合体的总数。
Genes Dev. 2018 Oct 1;32(19-20):1321-1331. doi: 10.1101/gad.315523.118. Epub 2018 Sep 18.
10
Mitotic Disassembly of Nuclear Pore Complexes Involves CDK1- and PLK1-Mediated Phosphorylation of Key Interconnecting Nucleoporins.核孔复合体的有丝分裂解体涉及细胞周期蛋白依赖性激酶1（CDK1）和polo样激酶1（PLK1）介导的关键连接核孔蛋白的磷酸化。
Dev Cell. 2017 Oct 23;43(2):141-156.e7. doi: 10.1016/j.devcel.2017.08.020.

引用本文的文献

1
Fission yeast essential nuclear pore protein Nup211 regulates the expression of genes involved in cytokinesis.裂殖酵母必需核孔蛋白Nup211调节参与胞质分裂的基因的表达。
PLoS One. 2024 Dec 12;19(12):e0312095. doi: 10.1371/journal.pone.0312095. eCollection 2024.
2
Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway.核孔蛋白TPR是TREX-2 mRNA输出途径的一个组成部分。
Nat Commun. 2020 Sep 11;11(1):4577. doi: 10.1038/s41467-020-18266-2.
3
Computational prediction and experimental validation of microRNAs in the brown alga Ectocarpus siliculosus.计算预测和实验验证褐藻石莼中的 microRNAs。
Nucleic Acids Res. 2014 Jan;42(1):417-29. doi: 10.1093/nar/gkt856. Epub 2013 Sep 26.
4
Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export.转运蛋白受体（Tpr）定位于核孔复合体的核篮中，并在核蛋白输出中发挥作用。
J Cell Biol. 2002 Feb 18;156(4):617-30. doi: 10.1083/jcb.200106046. Epub 2002 Feb 11.
5
Amino acid substitutions of coiled-coil protein Tpr abrogate anchorage to the nuclear pore complex but not parallel, in-register homodimerization.卷曲螺旋蛋白Tpr的氨基酸替换消除了其与核孔复合体的锚定作用，但并未影响其平行、对齐的同二聚化。
Mol Biol Cell. 2001 Aug;12(8):2433-52. doi: 10.1091/mbc.12.8.2433.
6
The nucleoporin Nup98 associates with the intranuclear filamentous protein network of TPR.核孔蛋白Nup98与TPR的核内丝状蛋白网络相关联。
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3208-13. doi: 10.1073/pnas.061014698.
7
Mammalian meiotic telomeres: protein composition and redistribution in relation to nuclear pores.哺乳动物减数分裂端粒：与核孔相关的蛋白质组成及重新分布
Mol Biol Cell. 2000 Dec;11(12):4189-203. doi: 10.1091/mbc.11.12.4189.

本文引用的文献

1
Nuclear RNA tracks: structural basis for transcription and splicing?核RNA轨迹：转录和剪接的结构基础？
Trends Cell Biol. 1993 Oct;3(10):346-53. doi: 10.1016/0962-8924(93)90105-a.
2
Nuclear pre-mRNA metabolism: channels and tracks.细胞核前体mRNA代谢：通道与轨迹
Trends Cell Biol. 1994 Feb;4(2):35-7. doi: 10.1016/0962-8924(94)90001-9.
3
NuMA: a protein involved in nuclear structure, spindle assembly, and nuclear re-formation.核有丝分裂器蛋白：一种参与核结构、纺锤体组装和核重建的蛋白质。
Trends Cell Biol. 1995 Feb;5(2):60-4. doi: 10.1016/s0962-8924(00)88947-3.
4
Intranuclear diffusion and hybridization state of oligonucleotides measured by fluorescence correlation spectroscopy in living cells.通过荧光相关光谱法在活细胞中测量寡核苷酸的核内扩散和杂交状态。
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6043-8. doi: 10.1073/pnas.95.11.6043.
5
Identification of an interchromosomal compartment by polymerization of nuclear-targeted vimentin.通过核靶向波形蛋白的聚合鉴定染色体间区室
J Cell Sci. 1998 May;111 ( Pt 9):1241-53. doi: 10.1242/jcs.111.9.1241.
6
Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr.核输入受体的主要结合位点是内核孔蛋白Nup153和相邻的核丝蛋白Tpr。
J Cell Biol. 1998 Apr 6;141(1):31-49. doi: 10.1083/jcb.141.1.31.
7
High-resolution field-emission scanning electron microscopy of nuclear pore complex.核孔复合体的高分辨率场发射扫描电子显微镜观察
Scanning. 1997 Aug;19(5):368-75. doi: 10.1002/sca.4950190504.
8
A Drosophila Tpr protein homolog is localized both in the extrachromosomal channel network and to nuclear pore complexes.一种果蝇Tpr蛋白同源物定位于染色体外通道网络和核孔复合体。
J Cell Sci. 1997 Apr;110 ( Pt 8):927-44. doi: 10.1242/jcs.110.8.927.
9
Anchorage-dependent cell cycle progression.锚定依赖性细胞周期进程。
J Cell Biol. 1997 Jan 13;136(1):1-4. doi: 10.1083/jcb.136.1.1.
10
The nuclear matrix protein p255 is a highly phosphorylated form of RNA polymerase II largest subunit which associates with spliceosomes.核基质蛋白p255是RNA聚合酶II最大亚基的一种高度磷酸化形式，它与剪接体相关联。
Nucleic Acids Res. 1996 Dec 1;24(23):4649-52. doi: 10.1093/nar/24.23.4649.

The Tpr protein: linking structure and function in the nuclear interior?

作者信息

Paddy M R

机构信息

Center for Structural Biology and Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610-0235, USA.

出版信息

Am J Hum Genet. 1998 Aug;63(2):305-10. doi: 10.1086/301989.

DOI:10.1086/301989
PMID:9683620
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1377329/
Abstract
摘要