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Coiled bodies and gems: Janus or gemini?

作者信息

Matera A G, Frey M R

机构信息

Department of Genetics, Center for Human Genetics, Center for RNA Molecular Biology and Program in Cell Biology, Case Western Reserve University School of Medicine, Cleveland, OH 44106-4955, USA.

出版信息

Am J Hum Genet. 1998 Aug;63(2):317-21. doi: 10.1086/301992.

DOI:10.1086/301992
PMID:9683623
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1377332/
Abstract
摘要

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Coiled bodies and gems: Janus or gemini?卷曲小体与宝石小体：双面还是双子？
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2
The spinal muscular atrophy disease gene product, SMN: A link between snRNP biogenesis and the Cajal (coiled) body.脊髓性肌萎缩症疾病基因产物，SMN：小核核糖核蛋白生物合成与卡哈尔（卷曲）体之间的联系。
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3
Absence of gemin5 from SMN complexes in nuclear Cajal bodies.核内 Cajal 体中 SMN 复合体缺乏 gemin5。
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4
Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis.肌萎缩侧索硬化症中双体卷曲体数量减少和 U12 snRNA 水平降低。
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5
Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies.U1、U2、U4/U6和U5小核核糖核蛋白颗粒在螺旋体中的转录依赖性共定位。
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6
The relationship between SMN, the spinal muscular atrophy protein, and nuclear coiled bodies in differentiated tissues and cultured cells.生存运动神经元（SMN），即脊髓性肌萎缩蛋白，与分化组织及培养细胞中的核卷曲小体之间的关系。
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Ultrastructural characterisation of a nuclear domain highly enriched in survival of motor neuron (SMN) protein.运动神经元存活蛋白（SMN）高度富集的核结构域的超微结构特征
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本文引用的文献

1
Of coiled bodies, gems, and salmon.关于螺旋小体、宝石和鲑鱼。
J Cell Biochem. 1998 Aug 1;70(2):181-92.
2
Heterogeneity of subcellular localization and electrophoretic mobility of survival motor neuron (SMN) protein in mammalian neural cells and tissues.哺乳动物神经细胞和组织中存活运动神经元（SMN）蛋白的亚细胞定位和电泳迁移率的异质性。
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6492-7. doi: 10.1073/pnas.95.11.6492.
3
SMN oligomerization defect correlates with spinal muscular atrophy severity.SMN寡聚化缺陷与脊髓性肌萎缩症的严重程度相关。
Nat Genet. 1998 May;19(1):63-6. doi: 10.1038/ng0598-63.
4
Coiled bodies and U2 snRNA genes adjacent to coiled bodies are enriched in factors required for snRNA transcription.螺旋体以及与螺旋体相邻的U2小核RNA基因富含小核RNA转录所需的因子。
Mol Biol Cell. 1998 May;9(5):1025-36. doi: 10.1091/mbc.9.5.1025.
5
Structure and function in the nucleus.细胞核的结构与功能
Science. 1998 Apr 24;280(5363):547-53. doi: 10.1126/science.280.5363.547.
6
Human genes encoding U3 snRNA associate with coiled bodies in interphase cells and are clustered on chromosome 17p11.2 in a complex inverted repeat structure.编码U3小核仁RNA的人类基因在间期细胞中与卷曲小体相关联，并且以复杂的反向重复结构聚集在17号染色体的11.2区带上。
Nucleic Acids Res. 1997 Dec 1;25(23):4740-7. doi: 10.1093/nar/25.23.4740.
7
Spinal muscular atrophy.脊髓性肌萎缩症
Curr Opin Neurol. 1997 Oct;10(5):381-5. doi: 10.1097/00019052-199710000-00005.
8
The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis.SMN-SIP1复合物在剪接体小核核糖核蛋白（snRNP）生物合成中起关键作用。
Cell. 1997 Sep 19;90(6):1023-9. doi: 10.1016/s0092-8674(00)80368-2.
9
The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.脊髓性肌萎缩症疾病基因产物SMN及其相关蛋白SIP1与剪接体snRNP蛋白形成复合物。
Cell. 1997 Sep 19;90(6):1013-21. doi: 10.1016/s0092-8674(00)80367-0.
10
Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos.存活运动神经元基因是人类脊髓性肌萎缩症的一个候选基因，该基因的失活会导致小鼠早期胚胎出现大量细胞死亡。
Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9920-5. doi: 10.1073/pnas.94.18.9920.