Schmich J, Trepel S, Leitz T
Zoologisches Institut der Universität, Abteilung Physiologie, Im Neuenheimer Feld 230, D-69120 Heidelberg, Germany.
Dev Genes Evol. 1998 Jul;208(5):267-73. doi: 10.1007/s004270050181.
The metamorphosis of many marine invertebrate larvae is induced by environmental signals. Upon reception of the cues, internal signals have to be set in motion to convey information to all cells of the larvae. For hydrozoan larvae it was hypothesised that ectodermal neurosensory cells at the anterior part are those cells receptive of the inducer. Recently, it was shown that novel peptides with a common GLWamide terminus are found in Cnidaria. These peptides are located in a specific subset of the anterior sensory cells. It was hypothesised that the neuropeptides represent an internal signal coordinating the metamorphic process. In the current study we present further evidence for this hypothesis. Induction of metamorphosis is very specific for the GLWamide terminus and amidation is essential. The potency to metamorphose is strongly correlated with the presence of GLWamide-immunoreactive cell bodies. Our data fit our hypothesis about a very important role of GLWamides in the initiation of the morphogenetic processes very well.
许多海洋无脊椎动物幼虫的变态是由环境信号诱导的。接收到这些信号后，必须启动内部信号，将信息传递给幼虫的所有细胞。对于水螅虫幼虫，有人提出前部的外胚层神经感觉细胞是接受诱导物的细胞。最近，研究表明在刺胞动物中发现了具有共同GLWamide末端的新型肽。这些肽位于前部感觉细胞的一个特定亚群中。有人提出神经肽代表协调变态过程的内部信号。在当前的研究中，我们为这一假设提供了进一步的证据。变态诱导对GLWamide末端非常特异，酰胺化是必不可少的。变态的能力与GLWamide免疫反应性细胞体的存在密切相关。我们的数据非常符合我们关于GLWamides在形态发生过程启动中起非常重要作用的假设。
