Schmich J, Rudolf R, Trepel S, Leitz T
Zoologisches Institut der Universität, Abteilung Physiologie, Im Neuenheimer Feld 230, D-69120 Heidelberg, Germany.
Cell Tissue Res. 1998 Oct;294(1):169-77. doi: 10.1007/s004410051167.
GLWamides are a recently described, novel family of neuropeptides in Cnidaria. Antibodies specific for the GLWamide terminus have been raised and used to evaluate the occurrence and localisation of immunopositive material in various Cnidaria in order to determine whether GLWamides are present and to obtain a first impression of the possible regulatory role of these neuropeptides. GLWamide immunoreactivity has been found in all species tested and is not confined to distinct life stages but is present during most of the life cycle of the Cnidaria. Additionally, GLWamides are expressed by different nerve cells at different life stages. GLWamide-immunoreactive cells constitute a subset of the neural equipment. Overall our data suggest that GLWamides generally occur in the nervous system of Cnidaria and that these peptides are multifunctional. Putative functions other than the control of development include the regulation of nematocyst discharge, muscle contraction and the regulation of gastric function.
GLW酰胺是最近在刺胞动物中发现的一类新的神经肽家族。已制备出针对GLW酰胺末端的特异性抗体，并用于评估各种刺胞动物中免疫阳性物质的出现和定位，以确定GLW酰胺是否存在，并初步了解这些神经肽可能的调节作用。在所有测试物种中均发现了GLW酰胺免疫反应性，且不限于特定的生命阶段，而是存在于刺胞动物生命周期的大部分时间。此外，GLW酰胺在不同的生命阶段由不同的神经细胞表达。GLW酰胺免疫反应性细胞构成神经结构的一个子集。总体而言，我们的数据表明GLW酰胺普遍存在于刺胞动物的神经系统中，并且这些肽具有多种功能。除了控制发育外，推测的功能还包括刺丝囊排放的调节、肌肉收缩和胃功能的调节。
