Kanitakis J, Bourchany D, Faure M, Claudy A
Laboratory of Dermatopathology, Department of Dermatology, Hospital Edouard-Herriot, 69437 Lyon Cedex 03, France.
Eur J Dermatol. 1998 Jul-Aug;8(5):339-42.
Peripherin is a neuronal intermediate filament reportedly expressed in neuroendocrine skin carcinomas and some melanocytic tumors. In order to assess the diagnostic usefulness of antibodies to peripherin in dermatopathology, we studied its expression in 68 skin tumors mostly of neural origin, and compared this expression with that of neurofilaments, a well-established neuronal marker. Antibodies to peripherin and neurofilaments both labeled dermal neurons present in normal skin and within the tumors. Specific labeling of tumor cells for peripherin was seen in only 2/5 neuroendocrine skin carcinomas, 3/18 benign nevi and 7/19 melanomas; even in these cases the percentage of tumor cells did not exceed 20%. We conclude that antibodies to peripherin may be used for the demonstration of cutaneous neurons in normal and diseased skin; however their diagnostic usefulness appears limited, less than that of antibodies to neurofilaments.
外周蛋白是一种神经元中间丝，据报道在神经内分泌性皮肤癌和一些黑素细胞肿瘤中表达。为了评估外周蛋白抗体在皮肤病理学中的诊断价值，我们研究了其在68例大多起源于神经的皮肤肿瘤中的表达，并将这种表达与神经丝（一种公认的神经元标志物）的表达进行了比较。外周蛋白抗体和神经丝抗体均标记了正常皮肤和肿瘤内的真皮神经元。仅在2/5的神经内分泌性皮肤癌、3/18的良性痣和7/19的黑色素瘤中观察到肿瘤细胞对外周蛋白的特异性标记；即使在这些病例中，肿瘤细胞的百分比也不超过20%。我们得出结论，外周蛋白抗体可用于在正常和患病皮肤中显示皮肤神经元；然而，它们的诊断价值似乎有限，低于神经丝抗体。
