Roquer J, Palomeras E, Knobel H, Pou A
Servei de Neurologia, Hospital del Mar, Autonomous University of Barcelona, Spain.
Cerebrovasc Dis. 1998 Jul-Aug;8(4):222-7. doi: 10.1159/000015855.
We report 8 patients with the acquired immunodeficiency syndrome (AIDS) and intracerebral haemorrhage. There were 7 men and 1 woman (mean age 37.2 years) with a mean CD4 count of 81.2/mm3. Alcohol abuse was recorded in 7 patients, intravenous drug use in 4, homosexual activity in 2, thrombocytopaenia in 1 and severe hypertension in 1. There were 5 lobar and 3 deep haemorrhages. Potential aetiologies of intracerebral haemorrhage included cerebral toxoplasmosis (n = 2), thrombocytopenia (n = 2), hypertension (n = 1) and cerebral tuberculosis (n = 1). Data of these patients were compared with those of 30 AIDS inpatients without brain haemorrhage matched by age and sex and no statistically significant differences in risk factors for AIDS except for alcohol abuse (> 80 g/day) (p = 0.045) were found. Causes of brain haemorrhage in AIDS patients are heterogeneous. The relationship between both conditions may be explained by the effect of several predisposing factors to stroke in association with AIDS-related complications. Intracerebral haemorrhage is a late and serious complication of AIDS (mortality 62.5%). The frequency of intracerebral haemorrhage in AIDS (1.0%) is higher than that expected in a general population of young adults.
我们报告了8例获得性免疫缺陷综合征（AIDS）合并脑出血的患者。其中男性7例，女性1例（平均年龄37.2岁），平均CD4细胞计数为81.2/mm³。7例患者有酗酒史，4例有静脉吸毒史，2例有同性恋行为，1例有血小板减少症，1例有重度高血压。脑出血部位为脑叶出血5例，深部出血3例。脑出血的潜在病因包括脑弓形虫病（2例）、血小板减少症（2例）、高血压（1例）和脑结核（1例）。将这些患者的数据与30例年龄和性别相匹配的无脑出血的AIDS住院患者的数据进行比较，发现除酗酒（>80克/天）外（p=0.045），AIDS危险因素无统计学显著差异。AIDS患者脑出血的病因是多方面的。两种情况之间的关系可能由几种与AIDS相关并发症相关的中风易感因素的作用来解释。脑出血是AIDS晚期的严重并发症（死亡率62.5%）。AIDS患者脑出血的发生率（1.0%）高于一般年轻成年人人群的预期发生率。
