Miller A R, Pisters P W, Lee J E, Janjan N A, Abbruzzese J L, Evans D B
Department of Surgical Oncology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Hepatogastroenterology. 1998 May-Jun;45(21):624-33.
The goal of multimodality therapy for localized pancreatic cancer is to maximize local-regional disease control and patient survival. In contrast to surgery for other solid tumors, prolonged recovery following pancreaticoduodenectomy may prevent the timely delivery of postoperative adjuvant therapy. Therefore, efforts at The University of Texas, M.D. Anderson Cancer Center have focused on the delivery of chemotherapy and radiation therapy prior to surgery in patients with localized pancreatic cancer. Clinical trials have emphasized the use of altered-fractionation schedules of radiation therapy combined with novel radiation-sensitizing agents. All treatment schemes aim to decrease toxicity and treatment time while improving therapeutic efficacy.
局部胰腺癌多模态治疗的目标是最大限度地实现局部区域疾病控制并提高患者生存率。与其他实体瘤手术不同，胰十二指肠切除术后较长的恢复时间可能会妨碍术后辅助治疗的及时进行。因此，德克萨斯大学MD安德森癌症中心致力于对局部胰腺癌患者在手术前进行化疗和放疗。临床试验强调采用改变分割方案的放疗并联合新型放射增敏剂。所有治疗方案都旨在降低毒性、缩短治疗时间，同时提高治疗效果。
