Akiyama T, Hasegawa T, Sejima T, Sahara H, Seto K, Saito H, Takashima S
Dept. of General and Digestive Surgery, Kanazawa Medical University, Ishikawa, Japan.
Hepatogastroenterology. 1998 May-Jun;45(21):665-71.
BACKGROUND/AIMS: This study was designed to assess the correlation of interleukin 6 (IL-6) with jaundice reduction by percutaneous transhepatic cholangio-drainage (PTCD) for obstructive jaundice.
We measured serum and bile IL-6 concentrations by enzyme linked immuno-sorbent assay before and after PTCD in 26 patients with obstructive jaundice. The patients were divided into two groups according to their bilirubin decrease rate.
Serum IL-6 levels measured before and after PTCD in the slowly decreasing bilirubin group ("poor" group) were significantly higher than those of the rapidly decreasing bilirubin group ("good" group). Measures of bile IL-6 in the "poor" group remained high from 3 to 14 days after PTCD in comparison with the "good" group.
These results suggest that circulating IL-6, as well as IL-6 in the bile, may be involved in the pathogenesis of obstructive jaundice, and play an important role in preventing the resolution of obstructive jaundice after PTCD.
背景/目的：本研究旨在评估白细胞介素6（IL-6）与经皮经肝胆道引流术（PTCD）治疗梗阻性黄疸后黄疸消退的相关性。
我们采用酶联免疫吸附测定法，对26例梗阻性黄疸患者PTCD术前、术后的血清及胆汁IL-6浓度进行了检测。根据胆红素下降率将患者分为两组。
胆红素下降缓慢组（“差效”组）PTCD术前、术后检测的血清IL-6水平显著高于胆红素下降迅速组（“高效”组）。与“高效”组相比，“差效”组PTCD术后3至14天胆汁IL-6水平持续处于高位。
这些结果表明，循环IL-6以及胆汁中的IL-6可能参与梗阻性黄疸的发病机制，并在阻碍PTCD术后梗阻性黄疸消退中发挥重要作用。
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