经皮经肝胆道引流术后血清及胆汁白细胞介素6

Serum and bile interleukin 6 after percutaneous transhepatic cholangio-drainage.

作者信息

Akiyama T, Hasegawa T, Sejima T, Sahara H, Seto K, Saito H, Takashima S

机构信息

Dept. of General and Digestive Surgery, Kanazawa Medical University, Ishikawa, Japan.

出版信息

Hepatogastroenterology. 1998 May-Jun;45(21):665-71.

PMID:9684114

Abstract

BACKGROUND/AIMS: This study was designed to assess the correlation of interleukin 6 (IL-6) with jaundice reduction by percutaneous transhepatic cholangio-drainage (PTCD) for obstructive jaundice.

METHODOLOGY

We measured serum and bile IL-6 concentrations by enzyme linked immuno-sorbent assay before and after PTCD in 26 patients with obstructive jaundice. The patients were divided into two groups according to their bilirubin decrease rate.

RESULTS

Serum IL-6 levels measured before and after PTCD in the slowly decreasing bilirubin group ("poor" group) were significantly higher than those of the rapidly decreasing bilirubin group ("good" group). Measures of bile IL-6 in the "poor" group remained high from 3 to 14 days after PTCD in comparison with the "good" group.

CONCLUSIONS

These results suggest that circulating IL-6, as well as IL-6 in the bile, may be involved in the pathogenesis of obstructive jaundice, and play an important role in preventing the resolution of obstructive jaundice after PTCD.

摘要

背景/目的：本研究旨在评估白细胞介素6（IL-6）与经皮经肝胆道引流术（PTCD）治疗梗阻性黄疸后黄疸消退的相关性。