Rastegar L A, Umrani G, Dehbashi N, Malec F
Department of Microbiology and Immunology, Iran University of Medical Sciences, Tehran, Iran.
Hepatogastroenterology. 1998 May-Jun;45(21):783-5.
BACKGROUND/AIMS: Hepatic cirrhosis is a common, chronic disease. Spontaneous bacterial peritonitis (SBP) is a dangerous complication, which must be treated as soon as it has been diagnosed. This usually requires hospitalization of the patient and parenteral antibiotic therapy for 10 to 14 days. The present study was carried out to compare the therapeutic effects of pefloxacin with ampicillin plus gentamicin in the management of SBP.
The patients were divided into two groups at random. Group A consisted of nine patients who received parenteral ampicillin plus gentamicin. Group B consisted of thirteen patients who received pefloxacin.
55% of patients in group A and 100% of patients in group B responded to treatment. No major side effects were observed in either of the groups.
Considering the benefits of oral treatment and the low incidence of side effects of pefloxacin we conclude that this regimen should be the treatment of choice for SBP patients, especially when there is a shortage of hospital beds.
背景/目的：肝硬化是一种常见的慢性疾病。自发性细菌性腹膜炎（SBP）是一种危险的并发症，一经诊断必须立即治疗。这通常需要患者住院，并进行10至14天的胃肠外抗生素治疗。本研究旨在比较培氟沙星与氨苄西林加庆大霉素治疗SBP的疗效。
将患者随机分为两组。A组由9名接受胃肠外氨苄西林加庆大霉素治疗的患者组成。B组由13名接受培氟沙星治疗的患者组成。
A组55%的患者和B组100%的患者对治疗有反应。两组均未观察到严重副作用。
考虑到口服治疗的益处以及培氟沙星副作用发生率较低，我们得出结论，该治疗方案应成为SBP患者的首选治疗方法，尤其是在医院床位短缺的情况下。
