Naito M, Nomura H, Iguchi A, Thompson W D, Smith E B
Department of Geriatrics, Nagoya University, School of Medicine, Japan.
Thromb Res. 1998 May 1;90(3):111-6. doi: 10.1016/s0049-3848(98)00027-9.
We evaluated the migration of vascular smooth muscle cells into crosslinked fibrin gels, using an in vitro assay system. Vascular smooth muscle cells from bovine fetal aorta migrated into non-crosslinked and crosslinked fibrin gels and showed a characteristic elongated spindle-shaped appearance with long cytoplasmic processes. The cells displayed two-fold increase in migration into crosslinked fibrin gels compared to non-crosslinked gels, suggesting the importance of fibrin crosslinking by factor XIIIa on its three-dimensional structure for the migration of smooth muscle cells.
