D'Antonio L L, Rice R D, Fink S C
Department of Surgery, Loma Linda University School of Medicine, California, USA.
Cleft Palate Craniofac J. 1998 Jul;35(4):333-41. doi: 10.1597/1545-1569_1998_035_0333_eopals_2.3.co_2.
This study described the occurrence and expression of pharyngeal and laryngeal anomalies in a population of patients with oculo-auriculo-vertebral spectrum (OAVS).
Cross-sectional study using chart review, physical examination, and endoscopic evaluation of the pharynx and larynx, and perceptual and aerodynamic evaluation of speech for assessment of vocal tract function.
Academic tertiary referral center.
Chart review of 41 patients with a diagnosis of OAVS and clinical evaluation of 23 of the patients identified in the initial chart review, ranging in age from 9 months to 17 years.
Data from chart review pertaining to airway and speech symptoms. Physical examination and endoscopic studies of pharyngeal and laryngeal structure and function and perceptual and aerodynamic evaluation of speech, resonance, and voice.
Chart review showed a high occurrence of indicators of pharyngeal and laryngeal abnormalities such as velopharyngeal inadequacy and airway obstruction. Clinical evaluations documented a variety of abnormalities in pharyngeal and laryngeal structure and function as well as impairment in speech articulation, resonance, and voice. Presence and severity of pharyngeal and laryngeal abnormalities were not correlated with the severity of expression of the spectrum based on mandibular morphology.
Oculo-auriculo-vertebral spectrum appears to be associated with a high occurrence of structural and functional abnormalities of the pharynx and larynx that may contribute to increased risk of airway obstruction, communication impairment, and morbidity.
本研究描述了眼-耳-脊椎综合征（OAVS）患者群体中咽和喉异常的发生情况及表现。
采用横断面研究，通过病历回顾、体格检查、咽和喉的内镜评估，以及语音的感知和空气动力学评估来评估声道功能。
学术性三级转诊中心。
对41例诊断为OAVS的患者进行病历回顾，并对初次病历回顾中确定的23例患者进行临床评估，年龄范围为9个月至17岁。
病历回顾中有关气道和语音症状的数据。咽和喉结构与功能的体格检查及内镜研究，以及语音、共鸣和嗓音的感知和空气动力学评估。
病历回顾显示咽和喉异常指标的发生率很高，如腭咽闭合不全和气道阻塞。临床评估记录了咽和喉结构与功能的各种异常，以及语音清晰度、共鸣和嗓音方面的损害。咽和喉异常的存在及严重程度与基于下颌形态的综合征表达严重程度无关。
眼-耳-脊椎综合征似乎与咽和喉的结构及功能异常的高发生率相关，这可能会增加气道阻塞、沟通障碍和发病的风险。
