Roosje P J, van Kooten P J, Thepen T, Bihari I C, Rutten V P, Koeman J P, Willemse T
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht, The Netherlands.
Vet Pathol. 1998 Jul;35(4):268-73. doi: 10.1177/030098589803500405.
The aim of this study was to characterize T cells in the skin of cats with an allergic dermatitis histologically compatible with atopic dermatitis, since T cells play an important role in the pathogenesis of atopic dermatitis in humans. We observed a significantly greater number of T cells in lesional skin of domestic short-haired cats with allergic dermatitis (n = 10; median age 5.8 years) than in the skin of healthy control animals (n = 10; median age 5.0 years). In the skin of the healthy control animals, one or two CD4+ cells and no CD8+ cells were found. A predominant increase of CD4+ T cells and a CD4+/CD8+ ratio (mean +/- SD: 3.9 +/- 2.0) was found in the lesional skin of 10 cats with allergic dermatitis. The CD4+/CD8+ cell ratio in the skin of healthy control animals could not be determined because of the absence of CD8+ cells. The CD4+/CD8+ cell ratio in the peripheral blood of 10 cats with allergic dermatitis (mean +/- SD: 1.9 +/- 0.4) did not differ significantly from that in 10 healthy control animals (2.2 +/- 0.4). The CD4+/CD8+ cell ratio and predominance of CD4+ T cells in the lesional skin of cats with allergic dermatitis is comparable to that found in atopic dermatitis in humans. In addition, the observed increase of CD4+ T cells in the nonlesional skin of cats with allergic dermatitis compared to the skin of healthy cats is similar to what is seen in humans. Cytokines produced by T cells and antigen-specific T cells are important mediators in the inflammatory cascade resulting in atopic dermatitis in humans. This study is a first step to investigate their role in feline allergic dermatitis.
本研究的目的是从组织学角度对患有与特应性皮炎组织学特征相符的过敏性皮炎的猫皮肤中的T细胞进行特征描述，因为T细胞在人类特应性皮炎的发病机制中起着重要作用。我们观察到，患有过敏性皮炎的家养短毛猫（n = 10；中位年龄5.8岁）的皮损皮肤中T细胞数量显著多于健康对照动物（n = 10；中位年龄5.0岁）的皮肤。在健康对照动物的皮肤中，发现一两个CD4 +细胞，未发现CD8 +细胞。在10只患有过敏性皮炎的猫的皮损皮肤中，发现CD4 + T细胞显著增加，CD4 + /CD8 +比值（平均值±标准差：3.9±2.0）升高。由于缺乏CD8 +细胞，无法确定健康对照动物皮肤中的CD4 + /CD8 +细胞比值。10只患有过敏性皮炎的猫的外周血中CD4 + /CD8 +细胞比值（平均值±标准差：1.9±0.4）与10只健康对照动物（2.2±0.4）相比，差异不显著。患有过敏性皮炎的猫的皮损皮肤中CD4 + /CD8 +细胞比值及CD4 + T细胞优势与人类特应性皮炎中的情况相当。此外，与健康猫的皮肤相比，患有过敏性皮炎的猫的非皮损皮肤中观察到的CD4 + T细胞增加与人类的情况相似。T细胞和抗原特异性T细胞产生的细胞因子是导致人类特应性皮炎的炎症级联反应中的重要介质。本研究是调查它们在猫过敏性皮炎中作用的第一步。
