Beresford J A, Crewther S G, Crewther D P
School of Optometry, University of New South Wales, Sydney, Australia.
Aust N Z J Ophthalmol. 1998 May;26 Suppl 1:S84-7. doi: 10.1111/j.1442-9071.1998.tb01383.x.
The present study compares morphological changes associated with optical defocus-induced myopia (ODM) with those from form deprivation myopia (FDM), as it is yet to be determined whether the latter is a consequence of visual deprivation or active myopic eye growth.
Hatchling chicks were reared for 2 weeks wearing a monocular translucent occluder or -10.00 D lens, with the other eye used as a control. After enucleation, eyes were processed for scanning electron microscopy.
Anatomical profiles of control eyes revealed significant variations in tissue thickness as a function of nasotemporal location. Both FDM and ODM eyes demonstrated similar morphological profiles of retinal thinning, cartilaginous scleral thickening, enlarged photoreceptor inner segments and decreased photoreceptor cell density towards the ora serrata. A graded differential orientation of photoreceptors existed in all eyes.
The comparable morphological changes in FDM and ODM suggest that the response to altered visual experience is similar in both paradigms.
本研究比较了与光学离焦诱导近视（ODM）相关的形态学变化和形觉剥夺性近视（FDM）的形态学变化，因为后者是视觉剥夺的结果还是近视性眼球的主动生长尚待确定。
将刚孵出的小鸡单眼佩戴半透明眼罩或-10.00 D透镜饲养2周，另一只眼作为对照。摘除眼球后，对眼睛进行扫描电子显微镜检查。
对照眼的解剖结构显示，组织厚度随鼻颞侧位置的不同而有显著差异。FDM眼和ODM眼均表现出相似的形态学特征，即视网膜变薄、软骨性巩膜增厚、光感受器内节增大以及朝向锯齿缘的光感受器细胞密度降低。所有眼睛的光感受器都存在分级差异取向。
FDM和ODM中可比的形态学变化表明，两种模式下对改变的视觉体验的反应相似。
