Liang H, Crewther D P, Crewther S G, Barila A M
School of Optometry, University of New South Wales, Kensington, Australia.
Vision Res. 1995 May;35(9):1217-25. doi: 10.1016/0042-6989(94)00241-d.
An ultrastructural examination of the outer retina and choroid of hatchling chicks reared for periods of 1, 2 or 4 weeks with opaque occluders (MD) covering one eye, was instigated to elucidate the mechanism of deprivation myopia. Refractive myopia (approximately 20 D), retinal and choroidal thinning were induced in all deprived eyes. Electron microscopy showed significant changes in the MD eyes compared to normals. Cone inner segments were markedly thicker and outer segment lamellae more damaged. The rod outer segments were elongated and thicker than normal, such that their distal tips either directly apposed the basal lamina of the retinal pigment epithelium, or indented the cell nuclei. We hypothesize that this "rod-push" mechanism leads to thinning of the choroid in deprived eyes, and may directly contribute to axial myopia.
对用不透明眼罩（MD）遮盖一只眼睛饲养1周、2周或4周的雏鸡的视网膜外层和脉络膜进行了超微结构检查，以阐明剥夺性近视的机制。所有被剥夺的眼睛均诱发了屈光性近视（约20 D）、视网膜和脉络膜变薄。电子显微镜检查显示，与正常眼睛相比，MD组眼睛有显著变化。视锥细胞内段明显增厚，外段板层损伤更严重。视杆细胞外段比正常的更长更厚，以至于其远端尖端要么直接贴附于视网膜色素上皮的基底层，要么压迫细胞核。我们推测，这种“视杆细胞推动”机制会导致被剥夺眼睛的脉络膜变薄，并可能直接导致轴性近视。
