Shugars D C, Wahl S M
Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill 27599-7450, USA.
J Am Dent Assoc. 1998 Jul;129(7):851-8. doi: 10.14219/jada.archive.1998.0349.
Human immunodeficiency virus type 1, or HIV-1, is infrequently transmitted through the mouth, unlike other mucosal sites. Factors such as low salivary viral titers, low numbers of CD4-positive target cells, anti-HIV antibodies and endogenous salivary antiviral factors work in concert to protect oral tissues from infection and reduce the risk of viral transmission through salivary secretions. This review summarizes the various factors thought to influence oral transmission HIV-1, focusing on the mucosal protein secretory leukocyte protease inhibitor, or SLPI.
与其他黏膜部位不同，1型人类免疫缺陷病毒（HIV-1）很少通过口腔传播。唾液病毒滴度低、CD4阳性靶细胞数量少、抗HIV抗体以及内源性唾液抗病毒因子等因素共同作用，保护口腔组织免受感染，并降低通过唾液分泌物传播病毒的风险。本综述总结了被认为影响HIV-1口腔传播的各种因素，重点关注黏膜蛋白分泌型白细胞蛋白酶抑制剂（SLPI）。
