Guzińska M, Kałuzny J, Florek G
Kliniki Okulistycznej AM w Bydgoszczy.
Klin Oczna. 1998;100(1):19-22.
One of the important points in extracapsular cataract extraction with posterior chamber intraocular lens implantation is to maintain mydriasis during the intervention. In this study we compared the efficacy of two topical nonsteroidal anti-inflammatory drugs: diclofenac sodium (Naclof) and indomethacin used before cataract surgery to inhibit surgically induced miosis.
Sixty-four patients were operated (ECCE with IOL) by three experienced surgeons. All patients received dilatating drops and nonsteroidal anti-inflammatory drugs every 30 minutes in five doses beginning 2.5 hours before surgery. 32 patients received diclofenac sodium and 32 patients indomethacin. Pupil diameters were measured three times: first--just before the initial limbal incision, second--at the end of cortical aspiration and the last after implantation of an intraocular lens.
In both groups the surgical manipulations induced a decrease in pupil diameter but more in the group treated with indomethacin.
Diclofenac sodium appeared to be more potent than indomethacin in maintaining intraoperative mydriasis during cataract surgery.
在白内障囊外摘除联合后房型人工晶状体植入术中，一个重要要点是在手术过程中维持瞳孔散大。在本研究中，我们比较了两种局部使用的非甾体类抗炎药：双氯芬酸钠（纳洛芬）和吲哚美辛在白内障手术前用于抑制手术诱发瞳孔缩小的效果。
64例患者由三位经验丰富的外科医生进行手术（白内障囊外摘除联合人工晶状体植入）。所有患者在手术前2.5小时开始，每30分钟接受一次散瞳滴眼液和非甾体类抗炎药，共五次剂量。32例患者接受双氯芬酸钠，32例患者接受吲哚美辛。瞳孔直径测量三次：第一次——在初始角膜缘切口前，第二次——在皮质吸出结束时，最后一次——在人工晶状体植入后。
两组手术操作均导致瞳孔直径减小，但吲哚美辛治疗组减小更明显。
在白内障手术中维持术中瞳孔散大方面，双氯芬酸钠似乎比吲哚美辛更有效。
