Wu X Y, Zhou Y
Faculty of Pharmacy, University of Toronto, Ontario, Canada.
J Control Release. 1998 Jan 23;51(1):57-71. doi: 10.1016/s0168-3659(97)00159-4.
This work concentrated on the analysis of several factors influencing the kinetics of diffusional drug release from complex matrix devices, such as convex tablets and rings, into a finite volume. These factors include initial drug concentration distribution, anisotropic matrix, and time- and concentration-dependent diffusion coefficients. The individual and comprehensive effects of these factors on the release kinetics were investigated by the finite element method. Errors introduced by neglecting drug diffusion through the ends of edges of cylindrical devices were estimated by comparison of the 1-D models with the 2-D cylinder model. The influence of side-wall coating on the accuracy of the prediction of release profiles by the 1-D slab model for cylindrical devices was studied using various coating materials of different permeabilities. The analyses carried out in this work could assist the design of the complex matrix systems required for controlled drug release.
这项工作专注于分析影响药物从复杂基质装置（如凸片和环）向有限体积扩散释放动力学的几个因素。这些因素包括初始药物浓度分布、各向异性基质以及时间和浓度依赖性扩散系数。通过有限元方法研究了这些因素对释放动力学的单独和综合影响。通过将一维模型与二维圆柱模型进行比较，估计了忽略药物通过圆柱形装置边缘末端扩散所引入的误差。使用具有不同渗透率的各种涂层材料，研究了侧壁涂层对圆柱形装置一维平板模型预测释放曲线准确性的影响。这项工作中进行的分析有助于设计控释所需的复杂基质系统。
