Menéndez Capote R, Díaz Pérez L, Luzardo Suárez C
Instituto de Medicina Tropical Pedro Kourí.
Rev Cubana Med Trop. 1997;49(2):136-8.
8 patients with paludism diagnosis due to Plasmodium vivax and deficiency of glucose-6-phosphate dehydrogenase that should receive antipaludism radical treatment with primaquine were studied. It was determined that 87.5% of the patients presented hemolysis but its relation with the enzymatic activity was not significant (p > 0.05). 50% of the patients could not finish their treatment because of the appearance of important hemolysis. It is concluded that primaquine should not be used indiscriminately among those patients with deficit of glucose 6 phosphate dehydrogenase.
对8例因间日疟原虫感染且缺乏葡萄糖-6-磷酸脱氢酶而需用伯氨喹进行抗疟根治治疗的疟疾患者进行了研究。结果发现，87.5%的患者出现了溶血，但溶血与酶活性之间的关系并不显著（p>0.05）。50%的患者因出现严重溶血而无法完成治疗。结论是，对于葡萄糖-6-磷酸脱氢酶缺乏的患者，不应随意使用伯氨喹。
