Abrahamsohn I A
Departamento de Imunologia, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1998 Jan;31(1):117-21. doi: 10.1590/s0100-879x1998000100015.
Resistance to Trypanosoma cruzi infections is critically dependent on cytokine-mediated activation of cell-mediated immune effector mechanisms. This review focuses on the role of IL-10, TNF-alpha, IFN-gamma and IL-12 in controlling T. cruzi replication by the innate and specific immune systems of the vertebrate host. A study performed on mice with disrupted recombinase-activating genes (RAG/KO), which lack T and B lymphocytes, revealed the importance of IL-12, IFN-gamma and TNF-alpha in the resistance against T. cruzi mediated by the innate immune system. In addition, data from experiments using IL-10 KO, RAG/KO and double RAG/IL-10 KO mice indicating an in vivo regulatory role of IL-10 in innate and T. cruzi-specific immunity are discussed.
对克氏锥虫感染的抵抗力关键取决于细胞因子介导的细胞介导免疫效应机制的激活。本综述重点关注白细胞介素-10（IL-10）、肿瘤坏死因子-α（TNF-α）、干扰素-γ（IFN-γ）和白细胞介素-12（IL-12）在脊椎动物宿主的固有免疫系统和特异性免疫系统控制克氏锥虫复制中的作用。一项对缺乏T和B淋巴细胞的重组酶激活基因破坏小鼠（RAG/KO）进行的研究揭示了IL-12、IFN-γ和TNF-α在固有免疫系统介导的抗克氏锥虫抗性中的重要性。此外，还讨论了使用IL-10基因敲除小鼠、RAG/KO小鼠和双RAG/IL-10基因敲除小鼠的实验数据，这些数据表明IL-10在固有免疫和克氏锥虫特异性免疫中具有体内调节作用。
