Arnaud A, Lagueny A, Hermosilla E, Ferrer X, Vital C, Julien J
Service de Neurologie, CHU Hôpital Haut-Lévêque, Pessac.
Rev Neurol (Paris). 1997 Dec;153(12):785-9.
A 72-old-man with a dramatic weight loss, exhibited a mononeuritis multiplex of subacute onset, and myalgia. There was hypoesthesia and weakness on median and ulnar nerves bilaterally, and weakness on left femoral nerve. Electrodiagnostical studies showed an axonal pattern of neuropathy. There was a considerable hypereosinophilia on blood count without any aetiologia found on exhaustive explorations. The idiopathic hypereosinophilic syndrome with a mononeuritis multiplex was suggested. Histological findings were an acute myelino-axonal degeneration with endoneural oedema, without vasculitis nor eosinophil cell on nerve-biopsy. Dramatic improvement occurred with corticosteroids and immunosuppressive treatment.
一名72岁男性，体重急剧下降，表现为亚急性起病的多发性单神经炎和肌痛。双侧正中神经和尺神经存在感觉减退和无力，左侧股神经无力。电诊断研究显示为轴索性神经病模式。血常规显示嗜酸性粒细胞显著增多，详尽检查未发现任何病因。提示为伴有多发性单神经炎的特发性嗜酸性粒细胞增多综合征。组织学检查结果为急性髓鞘 - 轴索变性伴神经内膜水肿，神经活检未见血管炎和嗜酸性粒细胞。使用皮质类固醇和免疫抑制治疗后病情显著改善。
