Nietgen G W, Durieux M E
Department of Anesthesiology, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
Cell Adhes Commun. 1998 Mar;5(3):221-35. doi: 10.3109/15419069809040293.
Lysophosphatidate (LPA) is an intercellular phospholipid messenger with a wide range of biologic effects. The first discovered source of LPA in the human body were activated platelets, but several other sites of LPA generation are now known. The number of cellular interactions is also growing steadily and responses to the compound range wide, from induction of mitogenesis to neurite retraction. LPA acts via a specific G protein-coupled receptor, of which one or more subtypes may exist. Intracellularly, this receptor activates several heterotrimeric G proteins. LPA induces cell proliferation via the small GTP-binding proteins ras, and triggers actin-based cytoskeletal events through rho. This review describes the most relevant recent developments in our understanding of LPA signaling.
溶血磷脂酸（LPA）是一种具有广泛生物学效应的细胞间磷脂信使。人体中首次发现的LPA来源是活化的血小板，但现在已知还有其他几个LPA生成部位。细胞间相互作用的数量也在稳步增加，对该化合物的反应范围很广，从诱导有丝分裂到神经突回缩。LPA通过一种特定的G蛋白偶联受体发挥作用，可能存在一种或多种亚型。在细胞内，这种受体激活几种异源三聚体G蛋白。LPA通过小GTP结合蛋白ras诱导细胞增殖，并通过rho触发基于肌动蛋白的细胞骨架事件。本综述描述了我们对LPA信号传导理解方面最近最相关的进展。
