Moolenaar W H
Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Curr Opin Cell Biol. 1995 Apr;7(2):203-10. doi: 10.1016/0955-0674(95)80029-8.
Lysophosphatidic acid is an intercellular phospholipid messenger that is released from platelets (and probably other cells) and evokes multiple biological responses, ranging from induction of mitogenesis to neurite retraction, by activating a specific G protein coupled receptor. Recent studies indicate that the lysophosphatidic acid receptor acts via the small GTP-binding proteins Ras and Rho to stimulate cell proliferation and to trigger actin-based cytoskeletal events, respectively.
溶血磷脂酸是一种细胞间磷脂信使，由血小板（可能还有其他细胞）释放，通过激活特定的G蛋白偶联受体引发多种生物学反应，范围从诱导有丝分裂到神经突回缩。最近的研究表明，溶血磷脂酸受体分别通过小GTP结合蛋白Ras和Rho起作用，以刺激细胞增殖和触发基于肌动蛋白的细胞骨架事件。
