Suggs L J, Kao E Y, Palombo L L, Krishnan R S, Widmer M S, Mikos A G
Cox Laboratory for Biomedical Engineering, Rice University, Houston, TX 77251-1892, USA.
J Biomater Sci Polym Ed. 1998;9(7):653-66. doi: 10.1163/156856298x00073.
We describe the preparation and bulk characterization of a cross-linked poly(propylene fumarate-co-ethylene glycol), p(PF-co-EG), hydrogel. Eight block copolymer formulations were made varying four different design parameters including: poly(ethylene glycol) (PEG) molecular weight, poly(propylene fumarate) (PPF) molecular weight, copolymer molecular weight, and ratio of PEG to PPF. Two different cross-linking formulations were also tested, one with a cross-linking monomer and one without. The extent of the cross-linking reaction and the degree of swelling in aqueous solution were determined on copolymer formulations made without a cross-linking monomer. The values of molecular weight between cross-links, Mc ranged from 300 +/- 120 to 1190 +/- 320 as determined from swelling data (n = 3). The equilibrium volume swelling ratios, Q, varied from 1.5 +/- 0.1 to 3.0 +/- 0.1. This ratio was found to increase with increasing PEG content in the copolymer and decrease with increasing PPF molecular weight. The values for complex dynamic elastic moduli magnitudes of E*, ranged from 0.9 +/- 0.2 to 13.1 +/- 1.1 MPa for the formulations with the cross-linking monomer, N-vinyl pyrrolidinone (VP) (n = 3). The ultimate tensile stresses on the formulations made with VP ranged from 0.15 +/- 0.03 to 1.44 +/- 1.06 MPa, and tensile moduli ranged from 1.11 +/- 0.20 to 20.66 +/- 2.42 MPa (n = 5). All of the mechanical properties increased with increasing PPF molecular weight and decreased with increasing PEG content in the copolymer. These data show that the physical properties of p(PF-co-EG) hydrogels can be tailored for specific applications by altering the material composition.
我们描述了一种交联聚（富马酸丙二醇酯 - 共 - 乙二醇），即p(PF - co - EG)水凝胶的制备及其整体表征。制备了八种嵌段共聚物配方，改变了四个不同的设计参数，包括：聚乙二醇（PEG）分子量、聚富马酸丙二醇酯（PPF）分子量、共聚物分子量以及PEG与PPF的比例。还测试了两种不同的交联配方，一种含有交联单体，另一种不含。在不含交联单体的共聚物配方上测定了交联反应程度和在水溶液中的溶胀度。根据溶胀数据（n = 3）确定，交联点之间的分子量Mc值范围为300±120至1190±320。平衡体积溶胀率Q在1.5±0.1至3.0±0.1之间变化。发现该比例随共聚物中PEG含量的增加而增加，随PPF分子量的增加而降低。对于含有交联单体N - 乙烯基吡咯烷酮（VP）的配方（n = 3），复数动态弹性模量E*的大小值范围为0.9±0.2至13.1±1.1 MPa。用VP制备的配方的极限拉伸应力范围为0.15±0.03至1.44±1.06 MPa，拉伸模量范围为1.11±0.20至20.66±2.42 MPa（n = 5）。所有机械性能均随PPF分子量的增加而增加，随共聚物中PEG含量的增加而降低。这些数据表明，通过改变材料组成，可以针对特定应用定制p(PF - co - EG)水凝胶 的物理性能。
