Zhu Yuxiang, Guo Shenghan, Ravichandran Dharneedar, Ramanathan Arunachalam, Sobczak M Taylor, Sacco Alaina F, Patil Dhanush, Thummalapalli Sri Vaishnavi, Pulido Tiffany V, Lancaster Jessica N, Yi Johnny, Cornella Jeffrey L, Lott David G, Chen Xiangfan, Mei Xuan, Zhang Yu Shrike, Wang Linbing, Wang Xianqiao, Zhao Yiping, Hassan Mohammad K, Chambers Lindsay B, Theobald Taylor G, Yang Sui, Liang Liang, Song Kenan
Manufacturing Engineering, The School of Manufacturing Systems and Networks (MSN), Ira A. Fulton Schools of Engineering, Arizona State University (ASU), Mesa, AZ, 85212, USA.
School of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM), College of Engineering, University of Georgia, Athens, GA, 30602, USA.
Adv Healthc Mater. 2025 Jan;14(1):e2402571. doi: 10.1002/adhm.202402571. Epub 2024 Nov 5.
3D printing, also known as additive manufacturing, holds immense potential for rapid prototyping and customized production of functional health-related devices. With advancements in polymer chemistry and biomedical engineering, polymeric biomaterials have become integral to 3D-printed biomedical applications. However, there still exists a bottleneck in the compatibility of polymeric biomaterials with different 3D printing methods, as well as intrinsic challenges such as limited printing resolution and rates. Therefore, this review aims to introduce the current state-of-the-art in 3D-printed functional polymeric health-related devices. It begins with an overview of the landscape of 3D printing techniques, followed by an examination of commonly used polymeric biomaterials. Subsequently, examples of 3D-printed biomedical devices are provided and classified into categories such as biosensors, bioactuators, soft robotics, energy storage systems, self-powered devices, and data science in bioplotting. The emphasis is on exploring the current capabilities of 3D printing in manufacturing polymeric biomaterials into desired geometries that facilitate device functionality and studying the reasons for material choice. Finally, an outlook with challenges and possible improvements in the near future is presented, projecting the contribution of general 3D printing and polymeric biomaterials in the field of healthcare.
3D打印,也被称为增材制造,在功能性健康相关设备的快速原型制作和定制生产方面具有巨大潜力。随着聚合物化学和生物医学工程的进步,聚合物生物材料已成为3D打印生物医学应用中不可或缺的一部分。然而,聚合物生物材料与不同3D打印方法的兼容性仍存在瓶颈,以及诸如打印分辨率和速度有限等内在挑战。因此,本综述旨在介绍3D打印功能性聚合物健康相关设备的当前技术水平。首先概述3D打印技术的概况,接着考察常用的聚合物生物材料。随后,提供3D打印生物医学设备的示例,并将其分为生物传感器、生物致动器、软体机器人、能量存储系统、自供电设备以及生物绘图中的数据科学等类别。重点在于探索3D打印在将聚合物生物材料制造为有助于设备功能的理想几何形状方面的当前能力,并研究材料选择的原因。最后,展望近期的挑战和可能的改进,预测通用3D打印和聚合物生物材料在医疗保健领域的贡献。