Al-Nawas B, Shah P M
Klinikum der J.W. Goethe Universität, Medizinische Klinik III, Schwerpunkt Infektiologie, Frankfurt am Main, Germany.
J Antimicrob Chemother. 1998 Jun;41(6):655-8. doi: 10.1093/jac/41.6.655.
The intraphagocytic effects of ciprofloxacin and BAY 12-8039 (moxifloxacin), a new 8-methoxyquinolone, on Staphylococcus aureus showing various susceptibility patterns were examined and the results were compared with the activities of the drugs against extracellular bacteria. MICs of moxifloxacin and ciprofloxacin against methicillin-resistant and -susceptible staphylococci were 0.063 mg/L and 0.5 mg/L, respectively. Moxifloxacin was also active against methicillin-resistant S. aureus (MIC = 2 mg/L) that were resistant to ciprofloxacin (MIC = 32 mg/L). At concentrations of 0.1 x or 1 x MIC, both drugs showed only weak bacteriostatic effects against ingested and non-ingested staphylococci. At 10 x MIC, ciprofloxacin and moxifloxacin were bactericidal against both intracellular and extracellular S. aureus susceptible to oxacillin and against MRSA susceptible to ciprofloxacin. However, ciprofloxacin was bactericidal only at very high concentrations ranging from 5 mg/L to 320 mg/L. Against ciprofloxacin-resistant MRSA moxifloxacin was still active. The results suggest that moxifloxacin is active against intracellular staphylococci.
研究了环丙沙星和新型8-甲氧基喹诺酮类药物BAY 12-8039（莫西沙星）对表现出不同药敏模式的金黄色葡萄球菌的吞噬内效应，并将结果与这些药物对细胞外细菌的活性进行了比较。莫西沙星和环丙沙星对耐甲氧西林和对甲氧西林敏感的葡萄球菌的MIC分别为0.063mg/L和0.5mg/L。莫西沙星对耐环丙沙星（MIC = 32mg/L）的耐甲氧西林金黄色葡萄球菌（MIC = 2mg/L）也有活性。在0.1x或1x MIC浓度下，两种药物对摄入和未摄入的葡萄球菌仅表现出微弱的抑菌作用。在10x MIC时，环丙沙星和莫西沙星对易被苯唑西林的细胞内和细胞外金黄色葡萄球菌以及对环丙沙星敏感的耐甲氧西林金黄色葡萄球菌均有杀菌作用。然而，环丙沙星仅在5mg/L至320mg/L的非常高浓度下才有杀菌作用。对于耐环丙沙星的耐甲氧西林金黄色葡萄球菌，莫西沙星仍然有活性。结果表明莫西沙星对细胞内葡萄球菌有活性。
