G-四联体形成寡核苷酸ISIS 5320对SCID-hu Thy/Liv小鼠中1型人类免疫缺陷病毒感染的抑制作用
Inhibition of human immunodeficiency virus type 1 infection in SCID-hu Thy/Liv mice by the G-quartet-forming oligonucleotide, ISIS 5320.
作者信息
Stoddart C A, Rabin L, Hincenbergs M, Moreno M, Linquist-Stepps V, Leeds J M, Truong L A, Wyatt J R, Ecker D J, McCune J M
机构信息
Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, USA.
出版信息
Antimicrob Agents Chemother. 1998 Aug;42(8):2113-5. doi: 10.1128/AAC.42.8.2113.
Abstract
Viral replication was inhibited in a dose-dependent manner after administration of the phosphorothioate oligonucleotide TTGGGGTT (ISIS 5320) to human immunodeficiency virus type 1 (HIV-1)-infected SCID-hu Thy/Liv mice. Potent in vivo antiviral activity was observed against the T-cell-tropic molecular clone NL4-3; the agent was found to have weak activity against one primary HIV-1 isolate, and the agent was inactive against a second primary isolate.
摘要
将硫代磷酸酯寡核苷酸TTGGGGTT（ISIS 5320）施用于感染人免疫缺陷病毒1型（HIV-1）的SCID-hu Thy/Liv小鼠后，病毒复制以剂量依赖的方式受到抑制。观察到对T细胞嗜性分子克隆NL4-3具有强大的体内抗病毒活性；发现该药物对一种原发性HIV-1分离株具有较弱的活性，而对另一种原发性分离株无活性。
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