云芝对离子型X射线造影剂泛影酸盐及相关三碘苯甲酸酯的转化作用
Transformation of the ionic X-ray contrast agent diatrizoate and related triiodinated benzoates by Trametes versicolor.
作者信息
Rode U, Müller R
机构信息
Biotechnologie II, Technische Universität Hamburg-Harburg, D-21071 Hamburg, Germany.
出版信息
Appl Environ Microbiol. 1998 Aug;64(8):3114-7. doi: 10.1128/AEM.64.8.3114-3117.1998.
Iodinated X-ray contrast agents are considered to be nondegradable by microorganisms. The decomposition of the ionic X-ray contrast agents Diatrizoate (3,5-di(acetamido)-2,4,6-triiodobenzoic acid) and Iodipamide (3,3'-adipoyl-diimino-di(2,4,6-triiodobenzoic acid) and related triiodinated benzoates (Acetrizoate [3-acetylamino-2,4, 6-triiodobenzoic acid] and Aminotrizoate [3-amino-2,4, 6-triiodobenzoic acid]) by Trametes versicolor has been investigated. The fungus was able to transform all tested triiodinated benzoates cometabolically. During transformation of these compounds, iodide was released, but deiodination was not complete. T. versicolor liberated traces of 14CO2 from uniformly ring-14C-labeled Diatrizoate (3,5-di(acetamido)-2,4,6-triiodobenzoate). Various extracellular metabolites were detected during transformation of the different substances. In the transformation of Diatrizoate, the three main metabolites were identified as 3,5-di(acetamido)-2, 6-diiodobenzoic acid, 3,5-di(acetamido)-2,4-diiodobenzoic acid, and 3,5-di(acetamido)-2-iodobenzoic acid, suggesting reductive deiodinations in steps as initial transformation steps.
碘化X射线造影剂被认为不能被微生物降解。已经研究了杂色云芝对离子型X射线造影剂泛影酸盐（3,5-二（乙酰氨基）-2,4,6-三碘苯甲酸）、碘番酸（3,3'-己二酰二亚氨基二（2,4,6-三碘苯甲酸））以及相关的三碘苯甲酸酯（醋碘苯酸盐[3-乙酰氨基-2,4,6-三碘苯甲酸]和氨三碘苯甲酸盐[3-氨基-2,4,6-三碘苯甲酸]）的分解情况。该真菌能够通过共代谢作用转化所有测试的三碘苯甲酸酯。在这些化合物的转化过程中，碘化物被释放出来，但脱碘并不完全。杂色云芝从均匀环-14C标记的泛影酸盐（3,5-二（乙酰氨基）-2,4,6-三碘苯甲酸盐）中释放出微量的14CO2。在不同物质的转化过程中检测到了各种细胞外代谢产物。在泛影酸盐的转化过程中，三种主要代谢产物被鉴定为3,5-二（乙酰氨基）-2,6-二碘苯甲酸、3,5-二（乙酰氨基）-2,4-二碘苯甲酸和3,5-二（乙酰氨基）-2-碘苯甲酸，这表明逐步进行的还原脱碘是初始转化步骤。
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