Newball H H, Brahim S A
Thorax. 1976 Aug;31(4):410-3. doi: 10.1136/thx.31.4.410.
To determine the effects of alternate-day prednisone therapy on respiratory function in myasthenia gravis, eight patients were evaluated during "days on" and "days off" prednisone. The patients were treated with long-term (up to three years), high-single-dose, alternate-day oral prednisone. After patients had been controlled with alternate-day prednisone they had no episodes of acute respiratory insufficiency or myasthenic crises. Although a small reduction in respiratory function during the day off prednisone was seen in some patients, the change was not statistically significant for the group and was probably physiologically unimportant in most patients. The data indicate that in myasthenic patients who have no underlying lung disease respiratory function is not significantly compromised by administering the prednisone on alternate days.
为确定隔日泼尼松疗法对重症肌无力患者呼吸功能的影响，对8例患者在服用泼尼松的“服药日”和“停药日”进行了评估。患者接受长期（长达三年）、高单次剂量的隔日口服泼尼松治疗。患者在接受隔日泼尼松治疗病情得到控制后，未出现急性呼吸功能不全或重症肌无力危象发作。虽然部分患者在停用泼尼松当日呼吸功能略有下降，但该组变化无统计学意义，且对大多数患者可能在生理上并不重要。数据表明，对于无潜在肺部疾病的重症肌无力患者，隔日服用泼尼松不会显著损害其呼吸功能。
