Marzioni D, Mühlhauser J, Crescimanno C, Banita M, Pierleoni C, Castellucci M
Institute of Normal Human Morphology, University of Ancona, Italy.
Hum Reprod. 1998 Jun;13(6):1717-22. doi: 10.1093/humrep/13.6.1717.
The human placenta performs numerous functions during its limited lifespan and its survival is a necessary prerequisite for fetal nutrition, even in unfavourable conditions. BCL-2 is a proto-oncogene implicated in the regulation of cell death and survival without affecting cell proliferation. An extracellular matrix molecule involved in the reparative and degenerative processes in the human placenta is fibrin. We have analysed by immunohistochemistry the expression of BCL-2 and correlated it with fibrin deposits in placental tissues. In first and third trimester placentas BCL-2 was expressed in the syncytiotrophoblast. Only a few mesenchymal villi (first trimester) or terminal villi (third trimester) showed no staining in the syncytiotrophoblast. Villous cytotrophoblast, mesenchymal cells of the villous cores and extravillous cytotrophoblast of cell columns and cell islands were all negative for BCL-2. BCL-2 expression was enhanced in the syncytiotrophoblast overlying subtrophoblastic fibrin deposits. However, discontinuities and/or variations in intensity of BCL-2 expression characterized not only the villi showing perivillous fibrinoid but also those villi with a massive presence of fibrinoid in their cores. These data suggest that BCL-2 may be necessary for the preservation of the placenta during gestation as well as for the reparative processes of the trophoblast.
人类胎盘在其有限的寿命期间执行多种功能，即使在不利条件下，其存活也是胎儿营养的必要先决条件。BCL-2是一种原癌基因，参与细胞死亡和存活的调节，而不影响细胞增殖。纤维蛋白是一种参与人类胎盘修复和退变过程的细胞外基质分子。我们通过免疫组织化学分析了BCL-2的表达，并将其与胎盘组织中的纤维蛋白沉积相关联。在妊娠早期和晚期的胎盘中，BCL-2在合体滋养层中表达。只有少数间充质绒毛（妊娠早期）或终末绒毛（妊娠晚期）的合体滋养层没有染色。绒毛细胞滋养层、绒毛核心的间充质细胞以及细胞柱和细胞岛的绒毛外细胞滋养层对BCL-2均呈阴性。在覆盖滋养细胞下纤维蛋白沉积的合体滋养层中，BCL-2表达增强。然而，BCL-2表达的不连续性和/或强度变化不仅表现在显示绒毛周围纤维蛋白样物质的绒毛中，也表现在核心有大量纤维蛋白样物质的绒毛中。这些数据表明，BCL-2可能对妊娠期胎盘的保存以及滋养层的修复过程是必要的。
