Panicker A K, Mangels R A, Powers J B, Wade G N, Schneider J E
Center for Neuroendocrine Studies, Neuroscience and Behavior Program, and Department of Psychology, University of Massachusetts, Amherst, Massachusetts 01003-7720, USA.
Am J Physiol. 1998 Jul;275(1):R158-64. doi: 10.1152/ajpregu.1998.275.1.R158.
Food deprivation inhibits ovulatory cycles and estrous behavior in Syrian hamsters. Lesions of the area postrema (AP) prevented the suppression of estrous behavior in food-deprived hamsters, but they did not prevent the suppression of estrous cyclicity or the increase in running-wheel activity caused by food deprivation. Food deprivation or treatment with pharmacological inhibitors of glycolysis and fatty acid oxidation decreased estrogen-receptor immunoreactivity (ERIR) in the ventromedial hypothalamus (VMH), increased ERIR in the arcuate nucleus (Arc) and the posterior parvicellular paraventricular nucleus (PaPo), but had no effect on ERIR in the posterodorsal medial amygdala or the anterior parvicellular paraventricular nucleus. Lesions of the AP prevented the food deprivation-induced decrease in VMH ERIR and the increase in Arc ERIR, but they did not prevent the increase in ERIR in the PaPo. Thus, whatever physiological cues are produced by food deprivation, an intact AP is required for their transmission to the neural circuits controlling estrous behavior, VMH ERIR, and Arc ERIR. The AP is not essential for transmission of this information to the neural circuits controlling estrous cyclicity, running-wheel activity, or PaPo ERIR.
食物剥夺会抑制叙利亚仓鼠的排卵周期和发情行为。最后区（AP）损伤可防止食物剥夺的仓鼠发情行为受到抑制，但不能防止食物剥夺引起的发情周期抑制或转轮活动增加。食物剥夺或用糖酵解和脂肪酸氧化的药理学抑制剂处理会降低腹内侧下丘脑（VMH）中的雌激素受体免疫反应性（ERIR），增加弓状核（Arc）和后小细胞室旁核（PaPo）中的ERIR，但对后内侧杏仁核或前小细胞室旁核中的ERIR没有影响。AP损伤可防止食物剥夺引起的VMH中ERIR降低和Arc中ERIR增加，但不能防止PaPo中ERIR增加。因此，无论食物剥夺产生何种生理信号，完整的AP对于将其传递至控制发情行为、VMH ERIR和Arc ERIR的神经回路都是必需的。AP对于将此信息传递至控制发情周期、转轮活动或PaPo ERIR的神经回路并非必不可少。
