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肉毒杆菌毒素A治疗脑瘫:功能改善与残疾程度减轻。三例病例报告。

Treatment of cerebral palsy with botulinum toxin A: functional benefit and reduction of disability. Three case reports.

作者信息

Mall V, Heinen F, Linder M, Philipsen A, Korinthenberg R

机构信息

Department of Neuropediatrics, Children's Hospital, University of Freiburg, Germany.

出版信息

Pediatr Rehabil. 1997 Oct-Dec;1(4):235-7. doi: 10.3109/17518429709167364.

DOI:10.3109/17518429709167364
PMID:9689260
Abstract

Three patients with cerebral palsy are described suffering, respectively, of pes equinus, spasm of the m. teres major and flexion spasm of the hand, who were treated with botulinum toxin A. These patients demonstrate not only the local reduction of the muscular hyperactivity following treatment with botulinum toxin A but also the potential functional benefit resulting from such a treatment. Thus, local intramuscular injection of botulinum toxin A in children with cerebral palsy should be considered as part of a multidisciplinary treatment concept, since reduction of the disability and the functional improvements could have high impact on daily living activities.

摘要

本文描述了三名分别患有马蹄足、大圆肌痉挛和手部屈曲痉挛的脑瘫患者,他们接受了A型肉毒杆菌毒素治疗。这些患者不仅显示出在接受A型肉毒杆菌毒素治疗后局部肌肉活动亢进有所减轻,还体现了这种治疗所带来的潜在功能益处。因此,对于脑瘫患儿,局部肌肉注射A型肉毒杆菌毒素应被视为多学科治疗理念的一部分,因为残疾程度的降低和功能的改善可能会对日常生活活动产生重大影响。

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Toxins (Basel). 2022 Dec 28;15(1):20. doi: 10.3390/toxins15010020.
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Toxins (Basel). 2018 Apr 19;10(4):162. doi: 10.3390/toxins10040162.
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Botulinum toxin A as an adjunct to treatment in the management of the upper limb in children with spastic cerebral palsy (UPDATE).
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Cochrane Database Syst Rev. 2010 Jan 20;2010(1):CD003469. doi: 10.1002/14651858.CD003469.pub4.
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Botulinum toxin type A injection for management of upper limb spasticity in children with cerebral palsy: a literature review.A型肉毒毒素注射治疗小儿脑性瘫痪上肢痉挛:文献综述
Yonsei Med J. 2006 Oct 31;47(5):589-603. doi: 10.3349/ymj.2006.47.5.589.