Fraser R F, McAsey M E, Coney P
Department of Obstetrics & Gynecology, Southern Illinois University School of Medicine, Springfield, USA.
Am J Reprod Immunol. 1998 Jul;40(1):37-42. doi: 10.1111/j.1600-0897.1998.tb00386.x.
Serum concentrations of the heterodimeric glycoprotein inhibin-A (alpha-beta A) and its alpha-subunit increase during pregnancy. The placenta is the predominant source of inhibin during pregnancy, and a paracrine role in the trophoblast has been suggested. Elevated serum concentrations of inhibin alpha-subunit as well as the glycoprotein human chorionic gonadotropin (hCG) have been described in preeclamptic pregnancy. The objectives of this investigation were to compare serum concentrations of inhibin-A and inhibin pro-alpha C in preeclamptic and normotensive pregnancy, and to examine the relationship of hCG and inhibin-A in those pregnancies.
A case-control design using 32 patients with preeclampsia with a single fetus at 32-40 weeks of gestation and 34 gestation age-matched normotensive control subjects was used for this investigation. Solid-phase enzyme-linked immunosorbent assays were used to measure inhibin-A and inhibin pro-alpha C in sera. An immunoradiometric assay was used to measure intact hCG.
Inhibin-A and inhibin pro-alpha C concentrations were significantly elevated in the sera of women with preeclampsia compared with those concentrations in normotensive control subjects (P < 0.05). A relationship of inhibin-A or pro-alpha C with severity of preeclampsia was not observed. There was a significant positive correlation of serum hCG with both inhibin-A and pro-alpha C (P < 0.05).
Levels of inhibin-A and the subunit pro-alpha C are increased in pregnancies complicated by preeclampsia. These findings are potentially the effect of a paracrine role of inhibin-A in the development and proliferation of the trophoblast.
异二聚体糖蛋白抑制素 -A（α-βA）及其α亚基的血清浓度在孕期会升高。胎盘是孕期抑制素的主要来源，有人提出其在滋养层细胞中具有旁分泌作用。子痫前期妊娠中已发现抑制素α亚基以及糖蛋白人绒毛膜促性腺激素（hCG）的血清浓度升高。本研究的目的是比较子痫前期妊娠和血压正常妊娠中抑制素 -A和抑制素前αC的血清浓度，并研究这些妊娠中hCG与抑制素 -A的关系。
本研究采用病例对照设计，选取32例孕32 - 40周单胎子痫前期患者和34例孕龄匹配的血压正常对照者。采用固相酶联免疫吸附测定法检测血清中的抑制素 -A和抑制素前αC。采用免疫放射测定法检测完整的hCG。
与血压正常的对照者相比，子痫前期女性血清中抑制素 -A和抑制素前αC的浓度显著升高（P < 0.05）。未观察到抑制素 -A或前αC与子痫前期严重程度之间的关系。血清hCG与抑制素 -A和前αC均呈显著正相关（P < 0.05）。
子痫前期妊娠中抑制素 -A和前αC亚基的水平升高。这些发现可能是抑制素 -A在滋养层细胞发育和增殖中旁分泌作用的结果。
