Mantovani A, Allavena P, Vecchi A, Sozzani S
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Int J Clin Lab Res. 1998;28(2):77-82. doi: 10.1007/s005990050023.
Chemokines are a superfamily of small cytokines which are generally chemotactic for leukocytes. The general features of chemokines and their receptors are reviewed. Recent evidence indicates that receptor expression dictates the spectrum of action of chemokines, as shown recently for Th1 and Th2 cells. Chemokines represent amplification loops of polarized Th1 and Th2 responses. Receptor expression is tightly regulated during differentiation, activation, and deactivation of mononuclear phagocytes and dendritic cells. Thus, regulation of receptor expression is crucial as a set point of the chemokine system.
趋化因子是一类小细胞因子的超家族，通常对白细胞具有趋化作用。本文综述了趋化因子及其受体的一般特征。最近的证据表明，受体表达决定了趋化因子的作用谱，正如最近在Th1和Th2细胞中所显示的那样。趋化因子代表了极化的Th1和Th2反应的放大环。在单核吞噬细胞和树突状细胞的分化、激活和失活过程中，受体表达受到严格调控。因此，受体表达的调控作为趋化因子系统的一个设定点至关重要。
