Arellanes-García L, Bautista N, Mora P, Ortega-Larrocea G, Burguet A, Gorodezky C
Uveitis Clinic, Dr. Luis Sánchez Bulnes Hospital, S.S.A., México.
Ocul Immunol Inflamm. 1998 Jun;6(2):93-100. doi: 10.1076/ocii.6.2.93.4049.
To analyze the genetic background of human leukocyte antigens (HLA) of Vogt-Koyanagi-Harada (VKH) disease in Mexican Mestizo patients in order to establish whether the pathogenesis is related to the same genes or sequences described in other populations.
In 48 VKH patients, we performed HLA class I and class II typing using the standard microlymphocytotoxicity tests; a group of 100 nonrelated healthy subjects were analyzed for comparison. Antigen and gene frequencies were calculated for every antigen tested in patients and in controls.
The frequency of HLA-DR4 was significantly increased in VKH Mexican patients (x2Y = 19.95; p = 0.00001; pc = 0.0002; RR = 5.3; EF = 0.52); a discrete increase in DR1 was also found (p = 0.02). HLA-DQ8 also showed a significant association with the disease with a lower RR (3.2) and EF (0.41) than DR4.
The strong association found with HLA-DR4 and the slight DR1 increase shown in Mexican patients with VKH suggest that a common shared sequence present in the third hypervariable region of DRB1 genes is relevant for the expression of the disease. The stronger association with DR4 than the one with DQ8 suggests that the DR locus carries the primary susceptibility genes involved in the pathogenesis of VKH.
分析墨西哥梅斯蒂索人患伏格特-小柳-原田病（VKH）患者的人类白细胞抗原（HLA）的遗传背景，以确定其发病机制是否与其他人群中描述的相同基因或序列相关。
对48例VKH患者，我们采用标准微量淋巴细胞毒性试验进行HLAⅠ类和Ⅱ类分型；分析100名无亲缘关系的健康受试者作为对照。计算患者和对照中检测的每种抗原的抗原频率和基因频率。
墨西哥VKH患者中HLA-DR4频率显著增加（x2Y = 19.95；p = 0.00001；pc = 0.0002；RR = 5.3；EF = 0.52）；还发现DR1有离散性增加（p = 0.02）。HLA-DQ8也显示与该疾病有显著关联，RR（3.2）和EF（0.41）低于DR4。
在墨西哥VKH患者中发现与HLA-DR4有强关联以及DR1有轻微增加，提示DRB1基因第三个高变区中存在的一个共同共享序列与该疾病的表达相关。与DR4的关联比与DQ8的关联更强，提示DR基因座携带参与VKH发病机制的主要易感基因。
