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一些源自3-芳氨基甲基-4-氨基-5-巯基-1,2,4-三唑的N-桥连杂环化合物的合成、光谱研究及生物活性

Synthesis, spectral studies and biological activities of some N-bridged heterocycles derived from 3-arylaminomethyl-4-amino-5-mercapto-1,2,4-triazoles.

作者信息

Holla B S, Udupa K V

机构信息

Department of P. G. Studies & Research in Chemistry Mangalore University, Mangalagangotri, India.

出版信息

Farmaco. 1992 Mar;47(3):305-18.

PMID:1503594
Abstract

Synthesis of four 3-arylaminomethyl-4-amino-5-mercapto-1,2,4-triazoles starting from substituted anilines is described. These triazoles were employed in the synthesis of some N-bridged heterocycles carrying arylaminomethyl substituents. All the newly synthesized compounds were characterized by analytical, NMR and mass spectral studies. Some of the newly synthesized compounds were screened for their antibacterial and antiviral properties.

摘要

描述了从取代苯胺出发合成四种3-芳基氨基甲基-4-氨基-5-巯基-1,2,4-三唑的方法。这些三唑被用于合成一些带有芳基氨基甲基取代基的N-桥连杂环。所有新合成的化合物均通过分析、核磁共振和质谱研究进行了表征。对一些新合成的化合物进行了抗菌和抗病毒性能筛选。

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