牛STAT5A cDNA的克隆与测序显示其与绵羊存在显著的序列差异。
Cloning and sequencing of the bovine STAT5A cDNA reveals significant sequence divergence with ovine.
作者信息
Schröder P, Meyer L, Wheeler T T, Thiesen H J, Seyfert H M
机构信息
Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere, Dummerstorf, Germany.
出版信息
Biochim Biophys Acta. 1998 Jun 16;1398(2):99-105. doi: 10.1016/s0167-4781(98)00054-2.
The transcription factors STAT5 mediates prolactin signals in mammary epithelial cells. The cDNA of bovine STAT5A was cloned, sequenced and compared to other species. The encoded protein proves to be > 95% homologous to other mammals. We show that the STAT5A mRNA of the closely related ovine species contains an extended (by 130 nt) 5'-untranslated region, being encoded by an extra-exon, and accounts, possibly, for improved translation efficiency.
转录因子STAT5介导乳腺上皮细胞中的催乳素信号。克隆并测序了牛STAT5A的cDNA，并与其他物种进行了比较。结果表明，其编码的蛋白质与其他哺乳动物的同源性>95%。我们发现，亲缘关系较近的绵羊物种的STAT5A mRNA含有一个延长的（延长130 nt）5'-非翻译区，由一个额外的外显子编码，这可能有助于提高翻译效率。
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