一例表现为外周血急性白血病且伴有复杂核型异常的急性巨核细胞白血病病例。
A case of acute megakaryocytic leukemia presenting as peripheral acute leukemia with complex karyotypic abnormalities.
作者信息
Xue Y, Lu D, Lu D, Li J, Guo Y, Xie X
机构信息
Jiangsu Institute of Haematology, Leukemia Research Unit, First Affiliated Hospital of Suzhou Medical College, People's Republic of China.
出版信息
Cancer Genet Cytogenet. 1998 Aug;105(1):83-5. doi: 10.1016/s0165-4608(98)00002-8.
Peripheral acute leukemia (PAL) is extremely rare. We report on the first case of acute megakaryocytic leukemia presenting with PAL and complex chromosomal abnormalities. At diagnosis, the patient had 10.5-21% marrow blasts and 55-60% peripheral blasts which expressed CD42b and CD61. Two related clones with the karyotype of 48,X,-X,+3,+9,del(9)(q12q31) x 2,+17,i(17)(q10)/ 49,idem, +18 were revealed by conventional cytogenetics, but no AML-1/ETO fusion transcript was detected by RT-PCR assay. The significance of this case is discussed concisely.
外周急性白血病（PAL）极为罕见。我们报告了首例表现为PAL并伴有复杂染色体异常的急性巨核细胞白血病病例。诊断时，患者骨髓原始细胞为10.5 - 21%，外周血原始细胞为55 - 60%，这些原始细胞表达CD42b和CD61。常规细胞遗传学检测发现两个相关克隆，核型分别为48,X,-X,+3,+9,del(9)(q12q31)×2,+17,i(17)(q10)/49,idem,+18，但逆转录聚合酶链反应（RT-PCR）检测未发现AML-1/ETO融合转录本。本文简要讨论了该病例的意义。
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