Mellman T A, Byers P M, Augenstein J S
University of Miami, School of Medicine, Department of Psychiatry and Behavioral Medicine, Florida 33136, USA.
J Trauma Stress. 1998 Jul;11(3):563-9. doi: 10.1023/A:1024460814230.
Early intervention aimed at secondary prevention is a high priority for posttraumatic stress disorder (PTSD) research. Disrupted sleep may have a role in the initiation and maintenance of PTSD. Three of the participants were recruited from a surgical trauma service, and one had sought treatment in a psychiatric setting. All were within 1-3 weeks of trauma exposure and had acute PTSD symptoms that included disturbed sleep. Temazepam, a benzodiazepine hypnotic, was administered for 5 nights, tapered for 2 nights, and then discontinued. Evaluations 1-week after the medication had been discontinued revealed improved sleep and reduced PTSD severity. These observations suggest an approach that may be clinically useful and a need for more systematic trials.
旨在二级预防的早期干预是创伤后应激障碍（PTSD）研究的高度优先事项。睡眠中断可能在PTSD的引发和维持中起作用。三名参与者从外科创伤服务部门招募，一名在精神科环境中寻求治疗。所有参与者都在创伤暴露后的1 - 3周内，并有包括睡眠障碍在内的急性PTSD症状。给予替马西泮（一种苯二氮䓬类催眠药）5晚，逐渐减量2晚，然后停药。停药1周后的评估显示睡眠改善，PTSD严重程度降低。这些观察结果提示了一种可能具有临床实用性的方法，以及进行更多系统试验的必要性。
