甘草查尔酮A：一种来自广藿香的细胞分化诱导剂和细胞毒剂。
Licochalcone A: an inducer of cell differentiation and cytotoxic agent from Pogostemon cablin.
作者信息
Park E J, Park H R, Lee J S, Kim J
出版信息
Planta Med. 1998 Jun;64(5):464-6. doi: 10.1055/s-2006-957485.
PMID:9690352
Abstract
Licochalcone A (1), ombuin (2), and 5,7-dihydroxy-3',4'-dimethoxyflavanone (3) were isolated from the aerial parts of Pogostemon cablin by cytotoxicity-guided fractionation. Compound 1 showed in vitro cytotoxicity and Pl-PLC gamma 1 inhibition activity. Treatment of promyelocytic leukemia cells (HL-60) with compound 1 induced terminal differentiation with the generation of monocyte using nonspecific acid esterase assay.
摘要
通过细胞毒性导向分级分离法从广藿香地上部分分离得到了地锦草素A（1）、澳洲茄碱（2）和5,7-二羟基-3',4'-二甲氧基黄烷酮（3）。化合物1表现出体外细胞毒性和磷脂酶Cγ1抑制活性。用化合物1处理早幼粒细胞白血病细胞（HL-60），通过非特异性酸性酯酶测定法诱导其终末分化并产生单核细胞。
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