一种来自中国甘草根的抗利什曼原虫查耳酮。

An antileishmanial chalcone from Chinese licorice roots.

作者信息

Christensen S B, Ming C, Andersen L, Hjørne U, Olsen C E, Cornett C, Theander T G, Kharazmi A

机构信息

Department of Organic Chemistry, Royal Danish School of Pharmacy, Copenhagen.

出版信息

Planta Med. 1994 Apr;60(2):121-3. doi: 10.1055/s-2006-959431.

DOI:10.1055/s-2006-959431

PMID:8202561

Abstract

A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.

摘要

对中国甘草根提取物进行生物测定导向的分级分离，得到了（E）-1-[2,4-二羟基-3-(3-甲基-2-丁烯基)phenyl]-3-[4-羟基-3-(3-甲基-2-丁烯基)phenyl]-2-丙烯-1-酮，该化合物在体外显示出强大的抗利什曼原虫活性。此外，还从根部分离出了新型查耳酮（E）-1-[2,4-二羟基-3-(3-甲基-2-丁烯基)phenyl]-3-(2,2-二甲基-8-羟基-2H-苯并吡喃-6-基)-2-丙烯-1-酮。后一种化合物仅在高浓度时显示出抗利什曼原虫活性。