Dolf G, Stricker C, Tontis A, Martig J, Gaillard C
Institute of Animal Breeding, University of Berne, Switzerland.
J Anim Sci. 1998 Jul;76(7):1824-9. doi: 10.2527/1998.7671824x.
The objective of this study was to establish the mode of inheritance of bovine dilated cardiomyopathy (BDCMP). We analyzed a pedigree comprising 75 animals in three age classes and five diagnostic classes based on clinical and pathological findings using the Pedigree Analysis Package. Segregation analyses were performed under three models, a major gene model, a mixed model, and an environment model. Under each model three data sets were analyzed. In the first data set, only animals with clinically manifested BDCMP were considered affected; in the second data set, animals with no clinical findings but with strong pathological evidence were included in the group of affected animals; and in the third data set, this group was extended to include animals that were suspected of having BDCMP. For all three data sets, a recessive allele at a single biallelic major locus controlling the underlying liability fitted the data best. Based on Akaike's information criterion, the major gene model was the most efficient model in all data sets. We conclude that a single biallelic major locus is likely responsible for the disease.
本研究的目的是确定牛扩张型心肌病（BDCMP）的遗传模式。我们使用谱系分析软件包，基于临床和病理结果，分析了一个包含三个年龄组和五个诊断类别的75只动物的谱系。在主要基因模型、混合模型和环境模型这三种模型下进行了分离分析。在每个模型下分析了三个数据集。在第一个数据集中，仅将临床表现为BDCMP的动物视为患病；在第二个数据集中，没有临床发现但有强有力病理证据的动物被纳入患病动物组；在第三个数据集中，该组扩展到包括疑似患有BDCMP的动物。对于所有三个数据集，控制潜在易感性的单个双等位基因主要位点上的隐性等位基因最符合数据。基于赤池信息准则，主要基因模型在所有数据集中是最有效的模型。我们得出结论，单个双等位基因主要位点可能是该疾病的病因。
