Tomidokoro A, Tamaki Y, Araie M, Tomita K, Muta K
Eye Clinic, Omiya Red Cross Hospital, Saitama, Japan.
Jpn J Ophthalmol. 1998 May-Jun;42(3):180-5. doi: 10.1016/s0021-5155(97)00132-9.
The effect of a single instillation of topical carteolol on iridial tissue circulation of pigmented rabbits was studied. The blood flow rate and a quantitative index of tissue blood velocity (NBiris) were measured simultaneously, using the microsphere technique and the laser speckle method, before and 2 hours after the instillation of 20 microliters of 2% carteolol or the vehicle. Consecutive changes of intraocular pressure and NBiris were also studied at 30-minute intervals for 2.5 hours after a single instillation of 2% carteolol in one eye and the vehicle in the contralateral eye. To provide a control, intraocular pressure and NBiris were measured according to the same schedule after the vehicle instillation in both eyes. Two hours after carteolol instillation, iridial blood flow rate and NBiris significantly increased to 127 +/- 8% and 122 +/- 9% (mean +/- SEM, n = 8) of the baseline. Unilateral instillation of carteolol significantly reduced intraocular pressure by about 9 mm Hg in both the carteolol- and vehicle-treated eyes (P < 0.001, analysis of variance); and NBiris was significantly increased by about 20% in both eyes (P < 0.001, analysis of variance), compared with control eyes.
研究了单次滴注局部用卡替洛尔对有色家兔虹膜组织循环的影响。在滴注20微升2%卡替洛尔或赋形剂之前和之后2小时，使用微球技术和激光散斑法同时测量血流速率和组织血流速度的定量指标（NBiris）。在一只眼睛单次滴注2%卡替洛尔而对侧眼睛滴注赋形剂后，还每隔30分钟研究2.5小时内眼压和NBiris的连续变化。为了提供对照，在双眼滴注赋形剂后按照相同时间表测量眼压和NBiris。滴注卡替洛尔2小时后，虹膜血流速率和NBiris显著增加至基线的127±8%和122±9%（平均值±标准误，n = 8）。单侧滴注卡替洛尔在卡替洛尔治疗组和赋形剂治疗组眼中均使眼压显著降低约9 mmHg（P < 0.001，方差分析）；与对照眼相比，双眼的NBiris均显著增加约20%（P < 0.001，方差分析）。
