Dahl M, Laursen L C
Medicinsk afdeling Y, Amtssygehuset i Gentofte.
Ugeskr Laeger. 1998 Jul 6;160(28):4231-3.
Effects and side effects of injectable depot steroid in the treatment of allergic rhinoconjunctivitis (hay fever) are described. A few controlled studies have shown injectable steroids to be superior to the effect of placebo and locally applied steroid. Over a period of 10 years from 1984-95 only 26 registered side effects were reported to the central Danish register for side effects of drugs (Laegemiddelstyrelsens Bivirkningsregister). Only eight concerned subcutaneous atrophy and in two cases the cutaneous changes persisted. Based on registration of number of treatments in the county of Funen 1996, it is estimated that the use of injectable depot steroids for treatment of hay fever accounts for about 535,000 DDD (defined daily doses corresponding to about 33,000 treatments per year). We conclude that the use of injectable corticosteroids in the treatment of hay fever is common and effective and side effects are very rare. However, injectable corticosteroids should only be used when conventional treatment is not sufficient to control symptoms.
本文描述了注射用长效类固醇在治疗变应性鼻结膜炎(花粉症)中的疗效和副作用。一些对照研究表明,注射用类固醇的效果优于安慰剂和局部应用类固醇。从1984年至1995年的10年间,丹麦药物副作用中央登记处(Laegemiddelstyrelsens Bivirkningsregister)仅收到26例关于注射用类固醇副作用的报告。其中仅有8例涉及皮下萎缩,且有2例皮肤改变持续存在。根据1996年菲英岛郡治疗次数的登记情况估算,注射用长效类固醇用于治疗花粉症的用量约为535,000限定日剂量(相当于每年约33,000次治疗)。我们得出结论,注射用皮质类固醇在治疗花粉症中应用普遍且疗效显著,副作用非常罕见。然而,仅在常规治疗不足以控制症状时才应使用注射用皮质类固醇。