Shimazu T, Matsushita H, Ishikawa K
Science. 1976 Oct 29;194(4264):535-6. doi: 10.1126/science.9692.
Cholinergic stimulation of the lateral hypothalamic neurons with intrahypothalamic microinjections of acetylcholine or carbachol caused a marked increase in the content of the active form of glycogen (starch) synthase in the liver. Total activity of the enzyme (active plus inactive forms) was not increased significantly. The lowest effective dose of acetylcholine was 5 X 10(-10) mole, and the optimum dose was 5 X 10(-9) mole. Similar applications of other neurotransmitters, such as norepinephrine, dopamine, serotonin, and gamma-aminobutyric acid, did not affect the enzyme's activity.
通过下丘脑内微量注射乙酰胆碱或卡巴胆碱对下丘脑外侧神经元进行胆碱能刺激，可导致肝脏中糖原（淀粉）合酶活性形式的含量显著增加。该酶的总活性（活性形式加非活性形式）并未显著增加。乙酰胆碱的最低有效剂量为5×10⁻¹⁰摩尔，最佳剂量为5×10⁻⁹摩尔。其他神经递质，如去甲肾上腺素、多巴胺、血清素和γ-氨基丁酸的类似应用，并未影响该酶的活性。
