大鼠离体下丘脑促肾上腺皮质激素释放激素的产生
Production of corticotrophin releasing hormone by the isolated hypothalamus of the rat.
作者信息
Buckingham J C, Hodges J R
出版信息
J Physiol. 1977 Nov;272(2):469-79. doi: 10.1113/jphysiol.1977.sp012054.
Abstract
- The ability of the rat hypothalamus to produce corticotrophin releasing hormone (CRH) in vitro was studied in the presence and absence of neurotransmitter substances, angiotensin and corticosterone. 2. Acetylcholine, 5-hydroxytryptamine (5-HT) and angiotensin II increased hypothalamic CRH release and content. 3. Noradrenaline and glycine decreased the spontaneous release of CRH from the hypothalamus but neither of these substances affected hypothalamic CRH content. 4. Dopamine, GABA, adrenaline, melatonin, histamine, glutamic acid and corticosterone did not affect the basal CRH activity of the hypothalamus in vitro. 5. Noradrenaline, GABA and corticosterone reduced the acetylcholine- and 5-HT-induced increases in the release of CRH from the hypothalamus. The rises in CRH content induced by acetylcholine and 5-HT were also reduced by noradrenaline and GABA but increased by corticosterone. 6. The physiological significance of the results and the potential value of the technique are discussed.
摘要
- 在有和没有神经递质物质、血管紧张素和皮质酮的情况下，研究了大鼠下丘脑在体外产生促肾上腺皮质激素释放激素（CRH）的能力。2. 乙酰胆碱、5-羟色胺（5-HT）和血管紧张素II增加下丘脑CRH的释放和含量。3. 去甲肾上腺素和甘氨酸减少下丘脑CRH的自发释放，但这两种物质均不影响下丘脑CRH的含量。4. 多巴胺、γ-氨基丁酸（GABA）、肾上腺素、褪黑素、组胺、谷氨酸和皮质酮在体外不影响下丘脑的基础CRH活性。5. 去甲肾上腺素、GABA和皮质酮减少乙酰胆碱和5-HT诱导的下丘脑CRH释放增加。去甲肾上腺素和GABA也降低了乙酰胆碱和5-HT诱导的CRH含量升高，但皮质酮使其增加。6. 讨论了结果的生理学意义和该技术的潜在价值。
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