Mutlu-Türkoglu U, Ademoglu E, Ibrahimoglu L, Aykaç-Toker G, Uysal M
Department of Biochemistry, University of Istanbul Faculty of Medicine, Capa, Turkey.
Gynecol Obstet Invest. 1998;46(1):37-40. doi: 10.1159/000009994.
Lipid peroxidation and the antioxidant system were investigated in the plasma and placenta of normal and preeclamptic pregnant women. A significant increase in thiobarbituric acid reactive substance (TBARS), significant decreases in total thiol (t-SH) content and superoxide dismutase (SOD) activity, and unchanged vitamin C levels and glutathione peroxidase (GPx) activity were observed in the plasma of preeclamptic women compared to women with normal pregnancies. In placentas from preeclamptic women TBARS levels were significantly elevated, while glutathione and vitamin C levels and GPx, glutathione S-transferase and SOD activities were decreased. After delivery, the elevated TBARS values decreased significantly and the reduced SOD activity and t-SH contents increased significantly. We concluded that preeclampsia is associated with an imbalance between lipid peroxides and the antioxidant system.
对正常孕妇和先兆子痫孕妇的血浆及胎盘进行脂质过氧化和抗氧化系统研究。与正常妊娠妇女相比，先兆子痫妇女血浆中硫代巴比妥酸反应物质（TBARS）显著增加，总硫醇（t-SH）含量和超氧化物歧化酶（SOD）活性显著降低，维生素C水平和谷胱甘肽过氧化物酶（GPx）活性无变化。先兆子痫妇女胎盘的TBARS水平显著升高，而谷胱甘肽、维生素C水平以及GPx、谷胱甘肽S-转移酶和SOD活性降低。分娩后，升高的TBARS值显著下降，降低的SOD活性和t-SH含量显著增加。我们得出结论，先兆子痫与脂质过氧化物和抗氧化系统之间的失衡有关。
