Stanier P, Abu-Hayyeh S, Murdoch J N, Eddleston J, Copp A J
Division of Paediatrics, Obstetrics and Gynaecology, Queen Charlotte's and Chelsea Hospital, Goldhawk Road, London, W6 OXG, United Kingdom.
Genomics. 1998 Jul 1;51(1):144-7. doi: 10.1006/geno.1998.5381.
SM22alpha (TAGLN) is one of the earliest markers of differentiated smooth muscle, being expressed exclusively in the smooth muscle cells of adult tissues and transiently in embryonic skeletal and cardiac tissues. We have identified and mapped the mouse Tagln gene and a closely related gene, Sm22alpha homolog (Tagln2). The chromosomal localization for Tagln was identified by linkage analysis to distal mouse chromosome 9 between D9Mit154 and D9Mit330, closely linked to the anchor locus D9Nds10. The localization of Tagln2 was also determined and was found to map between Fcgr2 and D1Mit149 on distal mouse chromosome 1. This localization is homologous to a region of human 1q21-q25 to which an EST representing human TAGLN2 was previously mapped. The two regions, distal mouse chromosome 1 and proximal mouse chromosome 9, and the human regions with conserved synteny (1q21-q25 and 11q22-qter) are believed to be paralogous, reflecting either conserved remnants of duplicated chromosomes or segments of chromosomes during vertebrate evolution.
SM22α（TAGLN）是分化型平滑肌最早出现的标志物之一，仅在成体组织的平滑肌细胞中表达，在胚胎骨骼肌和心脏组织中短暂表达。我们已经鉴定并定位了小鼠Tagln基因和一个密切相关的基因，即Sm22α同源物（Tagln2）。通过连锁分析确定Tagln定位于小鼠9号染色体远端D9Mit154和D9Mit330之间，与锚定基因座D9Nds10紧密连锁。还确定了Tagln2的定位，发现其定位于小鼠1号染色体远端的Fcgr2和D1Mit149之间。该定位与人类1q21-q25区域同源，先前一个代表人类TAGLN2的EST已定位到该区域。小鼠1号染色体远端和9号染色体近端这两个区域，以及具有保守同线性的人类区域（1q21-q25和11q22-qter）被认为是旁系同源的，反映了脊椎动物进化过程中重复染色体或染色体片段的保守残余。
