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[甲基胆蒽致癌过程中BALB/c和C57BL小鼠淋巴细胞的抗肿瘤活性]

[Antitumor activity of the lymphocytes of BALB/c and C57BL mice during methylcholanthrene carcinogenesis].

作者信息

Umanskiĭ Iu A, Semenova-Kobzar' R A, Kushko L Ia, Tovmachenko N N

出版信息

Vopr Onkol. 1976;22(6):40-4.

PMID:969342
Abstract

By means of the elaborated by the authors method of inhibition by lymphocytes of spheroids production by tumor cells a quantitative estimation of their antitumor activity is given in mice BALB/c and C57BL in methylcholanthrene carcinogenesis, Lymphoid cells in mice BALB/c proved to be more active functionally than lymphocytes in mice C57BL. Antitumor action of the lymphocytes is high enough at early stages of blastoma development, lymphocytes from remote lymph nodes being mostly active. At terminal stage the effector action of lymphocytes is diminished.

摘要

通过作者精心设计的淋巴细胞抑制肿瘤细胞球体生成的方法,对BALB/c和C57BL小鼠在甲基胆蒽致癌过程中的抗肿瘤活性进行了定量评估。结果表明,BALB/c小鼠的淋巴细胞在功能上比C57BL小鼠的淋巴细胞更活跃。在母细胞瘤发展的早期阶段,淋巴细胞的抗肿瘤作用足够高,来自远处淋巴结的淋巴细胞最为活跃。在终末期,淋巴细胞的效应作用减弱。

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