Singal D P, Li J, Ye M
Department of Pathology, McMaster University, Hamilton, Ontario, Canada.
Tissue Antigens. 1998 Jun;51(6):613-7. doi: 10.1111/j.1399-0039.1998.tb03003.x.
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease associated with HLA-DR genes that share a five amino acid sequence motif, QKRAA or QRRAA, from position 70 to 74 in the third hypervariable region of the DRbeta1 molecule. Since the associations between DRB1 genes and susceptibility to RA are incomplete, in this study we examined the CA repeat polymorphic marker DQCAR, located between DQA1 and DQB1 genes, alleles in 98 adult patients with seropositive RA and 100 normal healthy controls. The prevalence of the DQCAR 117 allele was significantly higher in RA patients as compared to normal controls. On the other hand, the frequency of DQCAR 99 was lower in patients than in normal subjects. Analysis of the data suggested that DRB1 genes sharing the QKRAA/QRRAA epitope have the primary association with disease susceptibility and DQCAR alleles do not provide an additional risk for the development of RA.
类风湿性关节炎（RA）是一种慢性炎症性关节疾病，与HLA - DR基因相关，这些基因在DRβ1分子的第三个高变区第70至74位共享一个五氨基酸序列基序，即QKRAA或QRRAA。由于DRB1基因与RA易感性之间的关联并不完全，在本研究中，我们检测了位于DQA1和DQB1基因之间的CA重复多态性标记DQCAR的等位基因，这些等位基因存在于98例血清阳性RA成年患者和100例正常健康对照中。与正常对照相比，RA患者中DQCAR 117等位基因的患病率显著更高。另一方面，患者中DQCAR 99的频率低于正常受试者。数据分析表明，共享QKRAA/QRRAA表位的DRB1基因与疾病易感性主要相关，而DQCAR等位基因并未为RA的发生提供额外风险。
