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p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation.
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P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2.
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Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2.
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本文引用的文献
1
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.
Genes Dev. 1998 Aug 1;12(15):2424-33. doi: 10.1101/gad.12.15.2424.
2
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2.
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8292-7. doi: 10.1073/pnas.95.14.8292.
3
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.
Cell. 1998 Mar 20;92(6):725-34. doi: 10.1016/s0092-8674(00)81401-4.
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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53.
Cell. 1998 Mar 20;92(6):713-23. doi: 10.1016/s0092-8674(00)81400-2.
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Viral transactivating proteins.
Annu Rev Genet. 1997;31:177-212. doi: 10.1146/annurev.genet.31.1.177.
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DNA damage induces phosphorylation of the amino terminus of p53.
Genes Dev. 1997 Dec 15;11(24):3471-81. doi: 10.1101/gad.11.24.3471.
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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.
Cell. 1997 Nov 28;91(5):649-59. doi: 10.1016/s0092-8674(00)80452-3.
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Splicing into senescence: the curious case of p16 and p19ARF.
Cell. 1997 Nov 28;91(5):555-8. doi: 10.1016/s0092-8674(00)80441-9.
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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2.
Cell. 1997 Oct 31;91(3):325-34. doi: 10.1016/s0092-8674(00)80416-x.
10
Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins.
Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12094-9. doi: 10.1073/pnas.94.22.12094.
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